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首页> 外文期刊>The journal of clinical investigation >Oncometabolites: linking altered metabolism with cancer
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Oncometabolites: linking altered metabolism with cancer

机译:瘤代谢物:将代谢改变与癌症联系起来

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The discovery of cancer-associated mutations in genes encoding key metabolic enzymes has provided a direct link between altered metabolism and cancer. Advances in mass spectrometry and nuclear magnetic resonance technologies have facilitated high-resolution metabolite profiling of cells and tumors and identified the accumulation of metabolites associated with specific gene defects. Here we review the potential roles of such “oncometabolites” in tumor evolution and as clinical biomarkers for the detection of cancers characterized by metabolic dysregulation.
机译:在编码关键代谢酶的基因中与癌症相关的突变的发现提供了新陈代谢和癌症之间的直接联系。质谱和核磁共振技术的进步促进了细胞和肿瘤的高分辨率代谢物谱分析,并确定了与特定基因缺陷相关的代谢物积聚。在这里,我们回顾了这种“代谢产物”在肿瘤进化中的潜在作用,并作为临床生物标记物用于检测以代谢失调为特征的癌症。

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