Isocitrate dehydrogenase mutations in leukemia

Anna Sophia McKenney; Ross L. Levine

首页> 外文期刊>The journal of clinical investigation >Isocitrate dehydrogenase mutations in leukemia

【24h】

Isocitrate dehydrogenase mutations in leukemia

机译：白血病中的异柠檬酸脱氢酶突变

获取原文

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Recent genome-wide discovery studies have identified a spectrum of mutations in different malignancies and have led to the elucidation of novel pathways that contribute to oncogenic transformation. The discovery of mutations in the genes encoding isocitrate dehydrogenase (IDH) has uncovered a critical role for altered metabolism in oncogenesis, and the neomorphic, oncogenic function of IDH mutations affects several epigenetic and gene regulatory pathways. Here we discuss the relevance of IDH mutations to leukemia pathogenesis, therapy, and outcome and how mutations in IDH1 and IDH2 affect the leukemia epigenome, hematopoietic differentiation, and clinical outcome.

机译：最近的全基因组发现研究已鉴定出不同恶性肿瘤中的一系列突变，并导致阐明了有助于致癌性转化的新途径。在编码异柠檬酸脱氢酶（IDH）的基因中发现突变，已揭示了在肿瘤发生中代谢改变的关键作用，IDH突变的新形态，致癌功能影响了几种表观遗传和基因调控途径。在这里，我们讨论IDH突变与白血病的发病机理，治疗和结果的相关性，以及IDH1和IDH2的突变如何影响白血病的表观基因组，造血分化和临床结果。

著录项

来源
《The journal of clinical investigation》 |2013年第9期|共6页
作者
Anna Sophia McKenney; Ross L. Levine;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种
中图分类临床医学;
关键词

相似文献

外文文献
中文文献
专利

1. Prognostic impact of isocitrate dehydrogenase enzyme isoforms 1 and 2 mutations in acute myeloid leukemia: a study by the Acute Leukemia French Association group. [J] . Boissel N, Nibourel O, Renneville A, Journal of Clinical Oncology . 2010,第23期

机译：急性髓性白血病中异柠檬酸脱氢酶同工型1和2突变对预后的影响：法国急性白血病协会的一项研究。
2. The long non-coding RNA Cancer Susceptibility 15 ( CASC15) is induced by isocitrate dehydrogenase (IDH) mutations and maintains an immature phenotype in adult acute myeloid leukemia [J] . Sarah Grasedieck, Christoph Ruess, Kathrin Krowiorz, Haematologica . 2020,第9期

机译：长期非编码RNA <斜体>癌症敏感性15 （<斜斜/ casc15 ）由异柠檬酸脱氢酶（IDH）突变诱导，并在成人急性髓性白血病中保持不成熟的表型
3. Isocitrate dehydrogenase 1 and 2 mutations, 2-hydroxyglutarate levels, and response to standard chemotherapy for patients with newly diagnosed acute myeloid leukemia [J] . Brunner Andrew M., Neuberg Donna S., Wander Seth A., Cancer: A Journal of the American Cancer Society . 2019,第4期

机译：异柠檬酸脱氢酶1和2突变，2-羟基戊酸水平，以及对新诊断的急性髓细胞白血病患者的标准化疗的反应
4. QUANTIFICATION OF SUBSTRATE AND INHIBITOR BINDING TO WILD TYPE AND MUTANT ISOCITRATE DEHYDROGENASE (IDH1) BY NON-DENATURING MASS SPECTROMETRY [C] . Victor Mikhailov, Shuang Liu, Christopher Schofield, International Mass Spectrometry Conference . 2018

机译：通过非变性质谱法定量基质和抑制剂与野生型和突变体相酯脱氢酶（IDH1）的结合
5. Predicting Isocitrate Dehydrogenase 1 (IDH1) Mutation in Patients with Gliomas using a Novel Deep Learning Network [D] . Xiao, Haonan. 2019

机译：使用小说深入学习网络预测胶质瘤患者的异偶酯脱氢酶1（IDH1）突变
6. Isocitrate Dehydrogenase Mutations in Myelodysplastic Syndromes and in Acute Myeloid Leukemias [O] . Ugo Testa, Germana Castelli, Elvira Pelosi 2020

机译：骨髓增生综合征和急性髓性白血病中的异柠檬酸脱氢酶突变
7. Isocitrate dehydrogenase 1 and 2 mutations, 2‐hydroxyglutarate levels, and response to standard chemotherapy for patients with newly diagnosed acute myeloid leukemia [O] . Andrew M. Brunner, Donna S. Neuberg, Seth A. Wander, 2018

机译：异柠檬酸脱氢酶1和2突变，2-羟基凝集水平，以及对新诊断的急性髓细胞白血病患者的标准化疗的反应

Isocitrate dehydrogenase mutations in leukemia

摘要

著录项

相似文献

相关主题

期刊订阅