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首页> 外文期刊>The Journal of Nuclear Medicine >Biodistribution and Radiation Dosimetry of 11C-Nicotine from Whole-Body PET Imaging in Humans
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Biodistribution and Radiation Dosimetry of 11C-Nicotine from Whole-Body PET Imaging in Humans

机译：人全身PET成像中11C-尼古丁的生物分布和辐射剂量测定

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id="p-2">This study assessed the in vivo distribution of 11C-nicotine and the absorbed radiation dose from whole-body 11C-nicotine PET imaging of 11 healthy (5 male and 6 female) subjects. >Methods: After an initial CT attenuation scan, 11C-nicotine was administered via intravenous injection. A dynamic PET scan was acquired for 90 s with the brain in the field of view, followed by a series of 13 whole-body PET scans acquired over a 90-min period. Regions of interest were drawn over organs visible in the reconstructed PET images. Time-activity curves were generated, and the residence times were calculated. The absorbed radiation dose for the whole body was calculated by entering the residence time in OLINDA/EXM 1.0 software to model the equivalent organ dose and the effective dose for a 70-kg man. >Results: The mean residence times for 11C-nicotine in the liver, red marrow, brain, and lungs were 0.048 ?± 0.010, 0.031 ?± 0.005, 0.021 ?± 0.004, and 0.020 ?± 0.005 h, respectively. The mean effective dose for 11C-nicotine was 5.44 ?± 0.67 ??Sv/MBq. The organs receiving the highest absorbed dose from the 11C-nicotine injection were the urinary bladder wall (14.68 ?± 8.70 ??Sv/MBq), kidneys (9.56 ?± 2.46 ??Sv/MBq), liver (8.94 ?± 1.67 ??Sv/MBq), and spleen (9.49 ?± 3.89 ??Sv/MBq). The renal and hepatobiliary systems were the major clearance and excretion routes for radioactivity. >Conclusion: The estimated radiation dose from 11C-nicotine administration is relatively modest and would allow for multiple PET examinations on the same subject.
机译：id =“ p-2”>这项研究评估了 11 C-尼古丁的体内分布和从全身 11 C-尼古丁PET吸收的辐射剂量11位健康受试者（5位男性和6位女性）的成像。 >方法：最初的CT衰减扫描后，通过静脉注射方式施用了 11 C-尼古丁。在视野内用大脑进行动态PET扫描90秒钟，然后在90分钟内进行一系列13次全身PET扫描。在重建的PET图像中可见的器官上绘制感兴趣的区域。生成时间-活动曲线，并计算停留时间。通过在OLINDA / EXM 1.0软件中输入停留时间来计算整个人体的吸收辐射剂量，以模拟一个70公斤男性的等效器官剂量和有效剂量。 >结果： 11 C-烟碱在肝脏，红骨髓，脑和肺中的平均停留时间为0.048±0.010、0.031±0.005、0.021±± 0.004和0.020±0.005小时。 11 C-烟碱的平均有效剂量为5.44±±0.67 ?? Sv / MBq。从 11 C-尼古丁注射液中吸收剂量最高的器官是膀胱壁（14.68±±8.70 Sv / MBq），肾脏（9.56±±2.46 Sv / MBq）。 ，肝脏（8.94±±1.67 Sv / MBq）和脾脏（9.49±±3.89 Sv / MBq）。肾脏和肝胆系统是放射性的主要清除和排泄途径。 >结论： 11 C-尼古丁给药的估计辐射剂量相对适中，可以对同一受试者进行多次PET检查。

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