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首页> 外文期刊>The Journal of Musculoskeletal and Neuronal Interactions >Quantitative ultrasonometry: An alternative and easy method to evaluate bone quality in people living with human immunodeficiency virus
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Quantitative ultrasonometry: An alternative and easy method to evaluate bone quality in people living with human immunodeficiency virus

机译：定量超声检查：评估人免疫缺陷病毒患者骨质的另一种简便方法

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Background: HIV infection and antiretroviral therapy (ART) are associated with bone mineral loss. DXA is the goldstandard method to evaluate the status of bone mineral density (BMD). However, it is not always readily available. Aneasy method is needed to evaluate bone quality in those infected with HIV. Objective: To evaluate portable quantitativeultrasonometry (QUS) as an alternative technique to provide information about bone density, bone strength, and the boneturnover markers in HIV-infected people. Methods: A total of 69 men took part (34 HIV-infected men were matched with35 non-HIV-infected men) in the study. Bone mineral status was assessed by the Achilles quantitative ultrasonometerat the calcaneal heel. The HIV status was recorded for all HIV-infected patients. Calcium-regulating hormones and boneturnover markers were assessed in all participants. Results: The mean age was 47.8±7.8 years and 49.1±6.00 years forthe HIV-infected and non-infected population, respectively. The bone quality expressed as Stiffness index (SI) was reducedin HIV-infected patients. Bone turnover markers were higher in the HIV-infected patients, P1NP (ng/mL) was 48.0±14.3vs 41.1±15.2 (P=0.057), and the (CTx)) (ng/mL) was 0.41±0.18 vs 0.29±0.11 (P=0.002). Conclusions: QUS is easyto use. Hence, QUS could be used as alternative method for screening of HIV patients for altered bone status.
机译：背景：HIV感染和抗逆转录病毒疗法（ART）与骨矿物质流失有关。 DXA是评估骨矿物质密度（BMD）状态的金标准方法。但是，它并不总是随时可用。需要一种简便的方法来评估艾滋病毒感染者的骨质。目的：评估便携式定量超声（QUS）作为一种替代技术，以提供有关HIV感染者的骨密度，骨强度和骨转换标记的信息。方法：本研究共纳入69名男性（其中34例HIV感染者与35例非HIV感染者匹配）。通过跟骨跟骨的Achilles定量超声仪评估骨矿物质状态。记录所有HIV感染患者的HIV状态。所有参与者均评估了钙调节激素和骨转换标志物。结果：HIV感染者和未感染者的平均年龄分别为47.8±7.8岁和49.1±6.00岁。感染了HIV的患者的骨质指数（刚度指数（SI））降低。 HIV感染患者的骨转换指标更高，P1NP（ng / mL）为48.0±14.3vs 41.1±15.2（P = 0.057），（CTx））（ng / mL）为0.41±0.18 vs 0.29± 0.11（P = 0.002）。结论：QUS易于使用。因此，QUS可以用作筛查HIV患者骨状态改变的替代方法。

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