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首页> 外文期刊>The Journal of Musculoskeletal and Neuronal Interactions >Correlations between the polymorphism of +869T/C in TGF-β1 and rheumatoid arthritis
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Correlations between the polymorphism of +869T/C in TGF-β1 and rheumatoid arthritis

机译：TGF-β1+ 869T / C位点多态性与类风湿关节炎的相关性

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Objective: To explore the correlations between the polymorphism of the gene first exon +869T/C in transforminggrowth factor-β1 (TGF-β1) and rheumatoid arthritis (RA). Methods: The patient group included 150 RA patients at theDepartment of Rheumatology in the First Affiliated Hospital of Chengdu Medical College between March 2014 and May2017 and 150 healthy cases as the control group. The polymorphism was analyzed using polymerase chain reactionrestrictionfragment length polymorphism (PCR-RFLP) and relationships between RA patients and genotypes wereanalyzed using logistic regression. Results: The genotype frequency distribution and the genotype frequency of +869T/Clocus was statistically different between two groups (P0.05). Compared to the control group, the genotype frequencyof +869 CC in the inpatient group was significantly lower (17.3% vs 32.7%), while the genotype frequency of +869 TTincreased significantly (29.3% vs 20.7%). The T allele frequency in inpatient group was significantly higher than thatin control group (57.83% vs 48.82%), while the C allele frequency in control group was significantly higher than thatin inpatient group (51.18% vs 42.17%). Conclusion: The polymorphism of the gene first exon +869T/C in TGF-β1significantly correlated with RA and CC genotype might be the susceptible gene of RA.
机译：目的：探讨转化生长因子-β1（TGF-β1）和风湿性关节炎（RA）的第一个外显子+ 869T / C基因多态性的相关性。方法：患者组包括2014年3月至2017年5月在成都医学院附属第一医院风湿科的RA患者150例，健康人150例为对照组。使用聚合酶链反应限制性片段长度多态性（PCR-RFLP）分析该多态性，并使用logistic回归分析RA患者与基因型之间的关系。结果：两组基因型频率分布和+ 869T / Clocus基因型频率差异有统计学意义（P <0.05）。与对照组相比，住院组+869 CC的基因型频率显着降低（17.3％对32.7％），而+869 TT的基因型频率显着增加（29.3％对20.7％）。住院组的T等位基因频率明显高于对照组（57.83％vs 48.82％），而对照组的C等位基因频率显着高于住院组（51.18％vs 42.17％）。结论：TGF-β1中第一个外显子+ 869T / C基因多态性与RA和CC基因型显着相关，可能是RA的易感基因。

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