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首页> 外文期刊>The Journal of Musculoskeletal and Neuronal Interactions >Whole body vibration at low-frequency can increase trabecular thickness and width in adult rats
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Whole body vibration at low-frequency can increase trabecular thickness and width in adult rats

机译：低频下的全身振动会增加成年大鼠的小梁厚度和宽度

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Objective: This study aimed to examine whether WBV becomes a possible modality for the primary prevention ofosteoporosis by exploring WBV frequency that has positive effects on bone properties in adult rats. Methods: Thirty-six24-week-old rats were divided into one control and 5 experimental groups, which underwent WBV at various frequencies(15, 30, 45, 60 or 90 Hz), with a magnitude of 0.5 g, for 15 min/day, 5 days/week, for 8 weeks. Bone size, muscleweight and bone mechanical strength were measured at the end of experimental period. Bone mass, trabecular bonemicroarchitecture (TBMA) and cortical bone geometry were analyzed by micro-CT. Circulating bone formation/resorptionmarkers were determined by ELISA. Results: Body weight-corrected soleus weight in all experimental groups and bodyweight-corrected extensor digitorum longus muscle weight in the 15 and 30 Hz groups were significantly higher thanthose of the control group, respectively. Femur trabecular thickness and width were significantly higher in the 15 Hz groupthan in the control group. However, there was no difference in bone mechanical strength or bone formation/resorptionmarkers among all groups. Conclusion: These results suggest that WBV at low-frequencies may become a potent modalityfor the primary prevention of osteoporosis in adults.
机译：目的：本研究旨在通过探索对成年大鼠骨特性有积极影响的WBV频率，研究WBV是否成为预防骨质疏松症的一种可能方式。方法：将36只24周大的大鼠分为一个对照组和5个实验组，分别以0.5 g的幅度（15、30、45、60或90 Hz）进行WBV，持续15 min /每天5天/周，共8周。在实验期结束时测量骨骼大小，肌肉重量和骨骼机械强度。骨质量，小梁骨微结构（TBMA）和皮质骨的几何形状通过微型CT分析。通过ELISA确定循环骨形成/再吸收标记。结果：所有实验组的体重校正后的比目鱼肌重量和15和30 Hz组的体重校正后的伸指长肌重量均显着高于对照组。 15 Hz组的股骨小梁厚度和宽度显着高于对照组。但是，所有组之间的骨机械强度或骨形成/再吸收标记均无差异。结论：这些结果表明，低频率的WBV可能成为一级预防成人骨质疏松的有效方法。

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