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首页> 外文期刊>The Journal of Musculoskeletal and Neuronal Interactions >Effects of grape seed proanthocyanidins extract on rat mandibular condyle
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Effects of grape seed proanthocyanidins extract on rat mandibular condyle

机译：葡萄籽原花青素提取物对大鼠下颌con突的影响

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We investigated the effects of grape seed proanthocyanidins extract (GSPE) on bone formation by examining total and corticalbone mass, density, architecture, and strength non-invasively using mandibular condyles of Ca-restricted rats. Forty Wistar male rats, each 5 weeks old, were divided into control (C), low-Ca diet (LCaD), low-Ca diet?standard diet (LcaD.SD) and low-Ca diet.Estandard diet with supplementary GSPE (LcaD.SD+GSPE) groups. In LCaD.SD group, after the bonedebility was induced by low-Ca diet, a standard diet therapy was given. In LCaD.SD+GSPE group, after the bone debility wasinduced by low-Ca diet, a standard diet therapy with supplementary GSPE was given. Each mandibular condyle was examinedusing peripheral quantitative computed tomography (pQCT). There were no significant inter-group differences in body weightseen throughout the experimental period. In LcaD.SD+GSPE, cortical bone cross-sectional area and mineral content werenot significantly different from C, while bone mineral content was significantly higher in LcaD.SD+GSPE than in LcaD.SD.Cortical bone density of LcaD.SD+GSPE was not significantly different from that of C, however, that value in LCaD andLcaD.SD was significantly lower than that. The cross-sectional (bending) moment of inertia values in LcaD.SD+GSPE werethe highest among all groups, though they did not differ significantly from those in C. Further, the cross-sectional (bending)Stress/Strain Index (SSI) values in LcaD.SD+GSPE were statistically similar to those in C, however, not significant higherthan in LcaD.SD. These results suggest that GSPE treatment would increase both bone mass and bone strength on the ratmandibular condyles.
机译：我们通过使用钙受限大鼠的下颌con进行无创检查总和皮质骨质量，密度，结构和强度，从而研究了葡萄籽原花青素提取物（GSPE）对骨骼形成的影响。将40只Wistar雄性大鼠每5周龄分为40只，分别为对照组（C），低钙饮食（LCaD），低钙饮食标准饮食（LcaD.SD）和低钙饮食。 LcaD.SD + GSPE）组。在LCaD.SD组中，低钙饮食诱发了骨质疏松症，然后进行了标准饮食疗法。在LCaD.SD + GSPE组中，低钙饮食诱发了骨质疏松症后，给予了标准饮食疗法，并补充了GSPE。使用外周定量计算机体层摄影术（pQCT）检查每个下颌con。在整个实验期间，体重没有显着的组间差异。在LcaD.SD + GSPE中，皮质骨的截面积和矿物质含量与C没有显着差异，而LcaD.SD + GSPE中的骨矿物质含量显着高于LcaD.SD + GSPE。与C的值没有显着差异，但是LCaD和LcaD.SD中的值显着低于C。 LcaD.SD + GSPE的横截面（弯曲）惯性矩值在所有组中最高，尽管它们与C值无显着差异。此外，横截面（弯曲）应力/应变指数（SSI） LcaD.SD + GSPE中的值在统计学上与C中相似，但是，并不比LcaD.SD中的显着更高。这些结果表明，GSPE治疗将增加下颌man突的骨量和骨强度。

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