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首页> 外文期刊>The Journal of Musculoskeletal and Neuronal Interactions >Muscle-bone relationships in mice selected for different body conformations
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Muscle-bone relationships in mice selected for different body conformations

机译：根据不同身体形态选择的小鼠的肌肉与骨骼的关系

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Some muscle-bone relationships were studied in terms of gastrocnemius muscle weight, femur and tibia length and femur and tibia weight in four lines of mice (CBi-, CBi+, CBi/L and CBi/C) artificially selected for different body conformations and in the unselected control line (CBi). CBi- (low body weight - short tail) and CBi+ (high body weight - long tail) lines were divergently selected following the positive genetic correlation between body weight and tail (skeleton) length (agonistic selection). In contrast, CBi/L (low body weight - long tail) and CBi/C (high body weight - short tail) were also divergently selected but against the aforementioned correlation (antagonistic selection). The relationship between bone length and muscle weight was interpreted based on the assumption that the increased tension generated by the longitudinal growth of a bone, brings about an increase in the mass of the muscles attached to it. All CBi+, CBi/C and CBi/L mice showed enlarged femurs and tibias, but only those genotypes simultaneously selected for high body weight (CBi+ and CBi/C) showed heavier muscles than controls. The CBi+ and CBi- genotypes with agonistic selection differ in bone length and muscle weight, as it would be expected of the allometric modification of their body conformation, showing the associated longitudinal bone growth-muscle growth. CBi/C and CBi/L mice, with a non-allometric modification of body conformation, exhibited the same bone length but different muscle weight. Consequently, the antagonistic criterion allowed to confirm that the genetic influence on of the proposed muscle-bone relationships could be modified, thus making it possible to lengthen the bone through selection of a long skeleton and to avoid the correlated effect on muscle mass, by selecting for a low body weight, bringing forth presumptive evidence that both processes were genetically independent.
机译：在腓肠肌重量，股骨和胫骨长度以及股骨和胫骨重量的四个系（CBi-，CBi +，CBi / L和CBi / C）中，针对不同的身体形态和体力，研究了一些肌肉骨骼关系。未选择的控制线（CBi）。根据体重与尾巴（骨骼）长度之间的正向遗传相关性（激动性选择），分别选择CBi-（低体重-短尾巴）和CBi +（高体重-长尾巴）品系。相反，CBi / L（低体重-长尾巴）和CBi / C（高体重-短尾巴）也被发散地选择，但与上述相关性（拮抗选择）相反。骨骼长度和肌肉重量之间的关系是基于这样的假设来解释的，即，骨骼纵向生长所产生的张力增加会导致附着在其上的肌肉质量增加。所有CBi +，CBi / C和CBi / L小鼠均显示股骨和胫骨增大，但是只有那些同时选择用于高体重的基因型（CBi +和CBi / C）才显示出比对照组更重的肌肉。具有激动作用选择的CBi +和CBi-基因型在骨长和肌肉重量上有所不同，因为可以预期它们的身体构象的异体修饰，显示出相关的纵向骨生长-肌肉生长。 CBi / C和CBi / L小鼠的身体构型经过非异形修饰，表现出相同的骨骼长度，但肌肉重量不同。因此，拮抗性标准可以确认对提议的肌肉骨骼关系的遗传影响可以被修改，从而可以通过选择长骨骼来延长骨骼长度，并通过选择避免对肌肉质量的相关影响。对于低体重，提出了两个过程在遗传上独立的推定证据。

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