The effects of exercise on skeletal muscle in the aged

M.S.F. Clarke

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The effects of exercise on skeletal muscle in the aged

机译：运动对老年人骨骼肌的影响

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Age-related sarcopenia leads to muscle weakness and a concomitant increase in gait problems and the risk of hip fracture due to falling in the elderly. Muscle weakness reduces general activity levels in elderly individuals which in turn elevates the risk of osteoporosis due to a decrease in overall mechanical loading of the skeleton. At the same time, age-related sarcopenia is also linked to an increase in the risk of metabolic disorders such as adult onset (Type II) diabetes. However, it is widely accepted that increased mechanical loading of the musculoskeletal system (e.g., resistive exercise) can have a beneficial effect on both skeletal muscle and the supporting skeleton resulting in a significant reduction in the risk of developing all of the above agerelated problems. As such, unloading models that exhibit many if not all of the same responses observed in aged muscle, including the capacity of exercise to reverse these responses, may provide valuable insight into the skeletal muscle aging process

机译：年龄相关的肌肉减少症会导致肌肉无力，步态问题随之增加，并因老年人跌倒而导致髋部骨折的风险。肌肉无力会降低老年人的一般活动水平，进而由于骨骼的整体机械负荷降低而增加骨质疏松症的风险。同时，与年龄相关的肌肉减少症也与诸如成人发病（II型）糖尿病等代谢性疾病的风险增加有关。但是，人们普遍接受的是，增加肌肉骨骼系统的机械负荷（例如抵抗运动）可以对骨骼肌和支撑骨骼都有有益的作用，从而大大降低了罹患上述所有与年龄有关的问题的风险。因此，在老年肌肉中观察到许多即使不是全部的相同反应，包括运动可以逆转这些反应的能力的卸荷模型，也可以提供对骨骼肌衰老过程的宝贵见解

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《The Journal of Musculoskeletal and Neuronal Interactions》 |2004年第2期|共页
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M.S.F. Clarke;
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The effects of exercise on skeletal muscle in the aged

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