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首页> 外文期刊>The Journal of Nuclear Medicine >Comparison of Cardiac Sympathetic Nervous Function with Left Ventricular Function and Perfusion in Cardiomyopathies by 123I-MIBG SPECT and 99mTc-Tetrofosmin Electrocardiographically Gated SPECT
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Comparison of Cardiac Sympathetic Nervous Function with Left Ventricular Function and Perfusion in Cardiomyopathies by 123I-MIBG SPECT and 99mTc-Tetrofosmin Electrocardiographically Gated SPECT

机译：123I-MIBG SPECT和99mTc-Tetrofosmin心电图门控SPECT对心脏交感神经功能与左心室功能及心肌病灌注的比较

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id="p-1">The objective of this study was to clarify the relationship between cardiac sympathetic nervous function (CSNF) and left ventricular (LV) function and perfusion in hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM). >Methods: Thirty-eight cases (32 males, 6 females; mean age, 56 ?± 15 y), consisting of 5 healthy control subjects, 15 patients with DCM, and 18 patients with HCM, were studied with 123I-metaiodobenzylguanidine (MIBG) and 99mTc-tetrofosmin SPECT. CSNF was evaluated from cardiac uptake and washout of MIBG, whereas LV perfusion and function were evaluated from tetrofosmin uptake and wall thickening on electrocardiographically gated SPECT. As quantitative parameters of global cardiac MIBG uptake and washout, the heart-to-mediastinum ratio (H/M) and percentage washout were calculated from early and delayed planar images. As quantitative regional parameters, the regional uptake and percentage washout of MIBG were calculated from SPECT images dividing the left ventricle into 12 segments. In the tetrofosmin study, the H/M and LV ejection fraction were calculated as the parameters of global LV perfusion and function. As quantitative regional parameters, the regional uptake and wall thickening were also calculated for the 12 myocardial segments using the quantitative gated SPECT software. Multiple linear regression analysis was performed to investigate the correlations between the parameters from the 2 studies. >Results: In DCM and HCM, multiple linear regression analysis of the regional parameters showed significant correlations between LV function and CSNF (P 0.0001) and between LV perfusion and CSNF (P 0.0001). According to the partial correlation coefficients, washout and early uptake of MIBG were the most significant factors for predicting LV function and LV perfusion, respectively. >Conclusion: In cardiomyopathies, CSNF was closely related to LV function. The quantitative parameters of MIBG washout could reflect cardiac functional impairment. Early MIBG uptake might be determined by myocardial perfusion in cardiomyopathies.
机译：id =“ p-1”>本研究的目的是阐明肥厚型心肌病（HCM）和扩张型心肌病（DCM）的心脏交感神经功能（CSNF）和左心室（LV）功能与灌注之间的关系。 >方法：研究了38例病例（男32例，女6例;平均年龄56？±15岁），包括5名健康对照者，15例DCM患者和18例HCM患者。用 123 I-甲硫基苄基胍（MIBG）和 99m Tc-四氟膦SPECT。 CSNF是通过心肌摄取和MIBG的洗脱来评估的，而LV灌注和功能是通过四磷酸磷铵的摄取和心电门控SPECT壁增厚来评估的。作为整体心肌MIBG摄取和清除的定量参数，可从早期和延迟的平面图像中计算出心脏与纵隔之比（H / M）和清除百分比。作为定量的区域参数，从SPECT图像中将MIBG的区域吸收和洗脱百分比计算为左心室分为12个部分。在tetrofosmin研究中，H / M和左室射血分数被计算为总体左室灌注和功能的参数。作为定量的区域参数，还使用定量门控SPECT软件计算了12个心肌节段的区域吸收和壁增厚。进行了多元线性回归分析，以研究来自2个研究的参数之间的相关性。 >结果：在DCM和HCM中，对区域参数进行的多元线性回归分析显示，LV功能与CSNF（ P <0.0001）之间以及LV灌注与CSNF（< em> P <0.0001）。根据偏相关系数，MIBG的洗脱和早期摄取分别是预测LV功能和LV灌注的最重要因素。 >结论：在心肌病中，CSNF与左室功能密切相关。 MIBG洗脱的定量参数可以反映心脏功能障碍。 MIBG的早期摄取可能是由心肌病中的心肌灌注决定的。

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