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首页> 外文期刊>The Internet Journal of Tropical Medicine >Cardioprotective Potential Of Vernonia Amygdalina And Ocimum Gratissimum Against Streptozotocin (Stz) – Induced Diabetes In Wistar Rats.
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Cardioprotective Potential Of Vernonia Amygdalina And Ocimum Gratissimum Against Streptozotocin (Stz) – Induced Diabetes In Wistar Rats.

机译：Vernyonia Amygdalina和Ocimum Gratissimum对链脲佐菌素（Stz）– Wistar大鼠诱发的糖尿病的心脏保护作用。

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Diabetes mellitus is characterized by disordered metabolism and abnormally high blood sugar resulting from insufficient levels of insulin. It is a disease of the developed world that is gradually creeping into developing countries, especially in Africa where Westernized diets are imbibed. Vernonia amygdalina and Ocimum gratissimum have been used singly for the management of diabetes in Nigeria, especially in the South Eastern part. The acceptance of the use of polyherbal therapy necessitated the research of the combination of these two herbs in the management of diabetes. Forty Wistar rats of an average weight of 140g were used for this study and were randomly divided into five (5) groups of eight (8) rats each. Groups A and B served as the normal and diabetic controls respectively and were given placebo treatment. Groups C, D and E were the experimental groups administered with 200mg/kg body weight of the extracts by gastric intubations for 28 days. Groups C and D received extracts of Vernonia amygdalina and Ocimum gratissimum respectively. Group E received a combination of both extracts. Fasting blood glucose (FBG) level was checked on a weekly basis. Results showed a significant lowering of FBG level of animals in the treated groups, while the diabetic control group recorded a significant increase in FBG. The normal control group had FBG level within the normal range. Histological examination revealed a normal cytoarchitecture in the group A animals. The diabetic control group B animals showed degeneration of myocytes, loss of nuclei, loss of cross striation of the cardiac muscles and an increase in myofibre diameter. These conditions were greatly reversed in the treated groups that received the extracts. It can therefore be concluded that Vernonia amygdalina and Ocimum gratissimum may be effective and safe in the proper management of cardiomyopathy, one of the numerous complications of diabetes mellitus. Introduction Diabetes is an age long, serious metabolic disorder with micro-vascular and macro- vascular complications that results in significant morbidity and mortality1. Chronic hyperglycemia during diabetes causes glycation of body protein which in turn leads to secondary complications that affect the eyes, kidneys, nerves and arteries2. These complications may be delayed, lessened or prevented by maintaining blood glucose levels close to normal 3. Cardiovascular disease is the major cause of mortality and morbidity in modern societies, among the numerous complications of diabetes 4. Long standing diabetes has been documented to cause structural and functional cardiac impairment, which was found to lead to ischemic heart disease, cardiomyopathy and congestive heart failure 5. It has been postulated that endothelial dysfunction, endomyocardia fibrosis; direct toxic effect of hyperglycemia on cardiomyocytes and autonomic neuropathy play an important role in diabetic cardiomyopathy 6. Diabetes has been identified by the World Health Organization (WHO) as an epidemic underway, since about 164 million people Worldwide were afflicted in 2000 and a possible increase to 366 million by 2030 has been projected 7. In Nigeria, the prevalence of diabetes according to a National survey reveals that 2.2 per cent (%); that is, 2-3 in every 100 person are suffering from the disease 8. The populations of people with this disease are found mostly in urban areas due to their sedentary life style 9. Despite these alarming figures and statistical data, a final therapy for now does not exist. However, therapeutic drugs have been in use since the accidental discovery of the hypoglycemic action of sulphonamides10. Consequently, herbal medicine, a new promising approach has emerged. It has been established that 40-60% of diabetics use non-conventional treatments, and 23% of this number use botanicals alone11. WHO in its general assembly authenticated this approach12, 13. Application of natural remedies for diabetes treatment has been further st
机译：糖尿病的特征是代谢紊乱和胰岛素水平不足引起的异常高血糖。它是一种发达国家的疾病，正逐渐蔓延到发展中国家，尤其是在吸收了西式饮食的非洲。在尼日利亚，特别是在东南部地区，杏仁核疫霉和免费赠送的Ocimum gratissimum已被单独用于糖尿病的管理。接受多草药疗法的接受使得有必要对这两种草药的组合进行糖尿病研究。四十只平均重量为140g的Wistar大鼠用于这项研究，并随机分为五（5）组，每组八（8）只。 A组和B组分别作为正常对照和糖尿病对照，并给予安慰剂治疗。 C，D和E组为实验组，通过胃插管给予28mg / kg体重的提取物28天。 C组和D组分别接受了苦杏仁Vernonia和免费的Ocimum gratissimum的提取物。 E组收到了两种提取物的组合。每周检查一次空腹血糖（FBG）水平。结果表明，治疗组动物的FBG水平显着降低，而糖尿病对照组记录到FBG显着升高。正常对照组的FBG水平在正常范围内。组织学检查显示A组动物细胞结构正常。糖尿病对照组B动物表现出心肌细胞的变性，核的丧失，心肌的交叉条纹的丧失以及肌纤维直径的增加。这些条件在接受提取物的治疗组中被大大逆转。因此可以得出结论，在适当处理心肌病（糖尿病众多并发症之一）的过程中，杏仁核紫癜和免费赠送的Ocimum gratissimum可能是有效和安全的。引言糖尿病是一种年龄长，严重的代谢紊乱，伴有微血管和大血管并发症，会导致高发病率和死亡率1。糖尿病期间的慢性高血糖症会导致人体蛋白质糖化，进而导致继发性并发症，影响眼睛，肾脏，神经和动脉2。通过使血糖水平维持在正常水平，可以延迟，减轻或预防这些并发症。3在许多糖尿病并发症中，心血管疾病是现代社会死亡率和发病率的主要原因。4。和功能性心脏损害，被发现可导致缺血性心脏病，心肌病和充血性心力衰竭。5据推测，存在内皮功能障碍，心内膜纤维化。高血糖对心肌细胞的直接毒性作用和自主神经病变在糖尿病性心肌病中起着重要作用。6.世界卫生组织（WHO）已将糖尿病确定为一种流行病，因为2000年全世界约有1.64亿人患有糖尿病，并且这种疾病有可能增加预计到2030年将达到3.66亿。7．在尼日利亚，根据一项全国调查，糖尿病的患病率是2.2％（％）。也就是说，每100人中就有2-3人患有这种疾病。8.由于久坐不动的生活方式，这种疾病的人们大多出现在城市地区。9尽管有这些令人震惊的数字和统计数据，这是一种最终的治疗方法。现在不存在。但是，自偶然发现磺胺类药物的降血糖作用以来，一直在使用治疗药物。因此，草药出现了一种新的有前途的方法。已经确定，40-60％的糖尿病患者使用非常规治疗，而其中23％的患者仅使用植物药11。世卫组织在其大会上对这种方法进行了验证12、13。进一步采用自然疗法治疗糖尿病

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