Imaging modalities for drug-related osteonecrosis of the jaw (3), Positron emission tomography imaging for the diagnosis of medication-related osteonecrosis of the jaw

Yoshimasa Kitagawa; Noritaka Ohga; Takuya Asaka; Jun Sato; Hironobu Hata; Joseph Helman; Kanako Tsuboi; Norio Amizuka; Yuji Kuge; Tohru Shiga

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Imaging modalities for drug-related osteonecrosis of the jaw (3), Positron emission tomography imaging for the diagnosis of medication-related osteonecrosis of the jaw

机译：颌骨药物相关性骨坏死的影像学检查方法（3），正电子发射断层扫描成像技术诊断颌骨药物相关性骨坏死

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Summary Medication-related osteonecrosis of jaws (MRONJ) is one of the most complicated inflammatory conditions in oral and maxillofacial region. It is very difficult to correctly evaluate the degree and extent of necrosis and infection. This refractory osteonecrosis often needs extended surgery, leading to impaired quality-of-life. We have performed hyperbaric oxygen therapy (HBO) combined with conservative surgery for advanced cases. We have appraised the value of FDG-PET and 3-phase bone scintigraphy in the diagnosis and management of this condition. MRONJ showed significantly higher SUVsubmax/sub on FDG-PET than the others. Although the 3 phase pool bone images did not change significantly, perfusion and static bone image as well as PET showed remarkable response to HBO for MRONJ. SUVsubmax/sub after HBO was significantly lower than those of before HBO. These preliminary results indicate that FDG-PET is useful for monitoring the effect of HBO for MRONJ.

机译：小结药物相关的颌骨坏死（MRONJ）是口腔和颌面部最复杂的炎症性疾病之一。正确评估坏死和感染的程度和程度非常困难。这种难治性骨坏死通常需要延长手术时间，从而导致生活质量受损。对于晚期病例，我们已经进行了高压氧疗法（HBO）结合保守手术。我们已经评估了FDG-PET和三相骨闪烁显像在该病的诊断和管理中的价值。 MRONJ在FDG-PET上显示的SUV _{max 明显高于其他。尽管三相池的骨图像没有显着变化，但对于MRONJ，灌注和静态骨图像以及PET对HBO表现出显着的反应。 HBO后的SUV _{max 显着低于HBO前。这些初步结果表明，FDG-PET可用于监测HBO对MRONJ的作用。}}

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《The Japanese dental science review.》 |2019年第1期|共6页
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Yoshimasa Kitagawa; Noritaka Ohga; Takuya Asaka; Jun Sato; Hironobu Hata; Joseph Helman; Kanako Tsuboi; Norio Amizuka; Yuji Kuge; Tohru Shiga;
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中图分类口腔科学;
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1. Symposium: Imaging modalities for drug-related osteonecrosis of the jaw (4), CT and MR imaging findings of antiresorptive agent-related osteonecrosis of the jaws/medication-related osteonecrosis of the jaw (secondary publication) [J] . Akira Baba, Hiroya Ojiri, Tazuko K. Goto, The Japanese dental science review. . 2019,第1期

机译：专题讨论会：颌骨药物相关性骨坏死的影像学检查方法（4），抗再吸收剂相关性颌骨坏死/药物相关的颌骨坏死的CT和MR影像学发现（二次出版）
2. ☆Symposium: Imaging modalities for drug-related osteonecrosis of the jaw (5), utility of bone scintigraphy and 18F-FDG PET/CT in early detection and risk assessment of medication-related osteonecrosis of the jaw (secondary publication) [J] . Satoru Watanabe, Kenichi Nakajima, Seigo Kinuya The Japanese dental science review. . 2019,第1期

机译：☆座谈会：下颌药物相关性骨坏死的影像学检查方法（5），骨闪烁显像和18F-FDG PET / CT在下颌药物相关性骨坏死的早期发现和风险评估中的应用（二次出版）
3. Imaging modalities for drug-related osteonecrosis of the jaw (2), Overview of the position paper on medication-related osteonecrosis of the jaw and the current status of the MRONJ in Japan [J] . Takahiko Shibahara The Japanese dental science review. . 2019,第1期

机译：颌骨药物相关性坏死的影像学模式（2），关于颌骨药物相关性坏死的立场文件概述以及日本MRONJ的现状
4. Design of a dual-modality, digital positron emission tomography/computed tomography (PET/CT) scanner for small animal imaging [C] . Fontaine, R., Michaud, Engineering in Medicine and Biology Society, 2003. Proceedings of the 25th Annual International Conference of the IEEE . 2003

机译：用于小动物成像的双模态数字正电子发射断层扫描/计算机断层扫描（PET / CT）扫描仪的设计
5. Osteonecrosis of the jaw: A clinical and functional imaging approach. [D] . Van Den Wyngaert, Tim. 2010

机译：颌骨坏死：一种临床和功能性成像方法。
6. Letter to the editor regarding Imaging modalities for drug-related osteonecrosis of the jaw (3) Positron emission tomography imaging for the diagnosis of medication-related osteonecrosis of the jaw [O] . E. Nastro Siniscalchi, F. Minutoli, S. Baldari, 2020

机译：关于编辑的关于颌骨相关骨折的成像方式（3）正电子发射断层扫描成像用于诊断下颚的药物相关骨折病症
7. Letter to the editor regarding “Imaging modalities for drug-related osteonecrosis of the jaw (3), Positron emission tomography imaging for the diagnosis of medication-related osteonecrosis of the jaw” [O] . E. Nastro Siniscalchi, F. Minutoli, S. Baldari, 2020

机译：关于编辑的关于“颌骨相关骨折的成像方式（3），正电子发射断层扫描成像，用于诊断下颚的药物相关骨折病症”

Imaging modalities for drug-related osteonecrosis of the jaw (3), Positron emission tomography imaging for the diagnosis of medication-related osteonecrosis of the jaw

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