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首页> 外文期刊>The Internet Journal of Toxicology >Pretreatment with Hypertonic Saline Outperforms Sodium Bicarbonate In Rodent Bupivacaine Toxicity
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Pretreatment with Hypertonic Saline Outperforms Sodium Bicarbonate In Rodent Bupivacaine Toxicity

机译：高渗盐水预处理对布比卡因啮齿类动物的毒性优于碳酸氢钠

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Bupivacaine is a commonly used local anesthetic agent with a significant cardiac adverse effect profile. Powerful experimental evidence has recently been published showing an effect for lipid emulsions in bupivacaine toxicity. Other studies have provided evidence of an effect for hypertonic sodium solutions. There is no evidence on whether the effects of lipid emulsion and hypertonic sodium solutions are additive. This preliminary study aims to establish which hypertonic sodium solution is most effective and create a model for future study. 24 female rats were divided into groups and pretreated with gelofusine?(control), hypertonic saline (HS) or sodium bicarbonate (NaBic) solution. Subjects were then infused with bupivacaine 0.75%. Outcomes were time to death and percent QRS duration prolongation two minutes into the infusion. HS pretreated animals survived bupivacaine infusion longer than NaBic (5.3+/-0.7 vs. 4.25+/-1.7 mins, p<0.05). Neither group was significantly different to controls for time to death. A protective effect for HS and NaBic on percent QRS prolongation 2 minutes into infusion occurred (8.8+/- 6.1%(HS) and 1.2+/-10.1% (NaBic) vs. 22 .8+/-15.0% p<0.05) with no siginificant difference between the 2 solutions. Increased lethal dose of bupivacaine in the HS group versus NaBic made it the most successful pretreatment. While no protective effect was found on time to death for either HS or NaBic, both had a protective effect on QRS duration prolongation 2 minutes into infusion, suggesting benefit. This variable can be included in future studies a priori.
机译：布比卡因是一种常用的局部麻醉剂，具有明显的心脏不良反应。最近已经发表了强有力的实验证据，显示脂质乳剂对布比卡因的毒性有作用。其他研究提供了高渗钠溶液作用的证据。没有证据表明脂质乳剂和高渗钠溶液的作用是否可加。这项初步研究旨在确定哪种高渗钠溶液最有效，并为将来的研究创造一个模型。将24只雌性大鼠分成几组，并用明胶碱（对照），高渗盐水（HS）或碳酸氢钠（NaBic）溶液预处理。然后向受试者注入0.75％的布比卡因。结果是输注两分钟后的死亡时间和QRS持续时间延长百分比。经HS预处理的动物比布比卡因输液的存活时间长于NaBic（5.3 +/- 0.7分钟对4.25 +/- 1.7分钟，p <0.05）。两组的死亡时间均无明显差异。 HS和NaBic对输注2分钟QRS延长百分比的保护作用发生了（8.8 +/- 6.1％（HS）和1.2 +/- 10.1％（NaBic）对22 .8 +/- 15.0％p <0.05）两种解决方案之间没有明显差异。与NaBic相比，HS组的布比卡因致死剂量增加，使其成为最成功的预处理方法。虽然在HS或NaBic的死亡时间中均未发现保护作用，但两者均对输注2分钟后QRS持续时间有保护作用，表明具有益处。该变量可以被包括在未来的研究中。

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