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首页> 外文期刊>The Internet Journal of Toxicology >Extreme Dose In Acute Zolpidem Intoxication
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Extreme Dose In Acute Zolpidem Intoxication

机译:急性唑吡坦中毒的极端剂量

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Zolpidem is a benzodiazepine-receptor-1-agonist and serves as a short-acting hypnotic agent for the treatment of insomnia and anxiety. Intoxications with Zolpidem, most in suicidal intent, are benign in the first place but can cause CNS and respiratory depression. Signs and symptoms are dose-regulated and exacerbated by co-ingestion of other CNS or respiratory depressants. Most clinical manifestations are somnolence, dizziness, amnesia, vomiting, ataxia and visual hallucinations with full recovery.We report a unique case of a man presenting in our Emergency Room with the highest recorded blood concentration (8.4 μg/ml) of Zolpidem and furthermore survived the overdose.
机译:唑吡坦是苯二氮卓类受体1激动剂,可作为失眠和焦虑症的短效催眠药。最初使用Zolpidem进行中毒的人大多数是自杀性的,但最初可能是良性的,但会导致CNS和呼吸抑制。其他中枢神经系统或呼吸抑制药的共吸入会调节体征和症状并加重症状。大多数临床表现是嗜睡,头晕,健忘,呕吐,共济失调和视觉幻觉,并且可以完全康复。我们报告了一名独特病例,一名男子出现在我们的急诊室,其唑吡坦的血药浓度最高(8.4μg/ ml),并且可以存活过量。

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