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首页> 外文期刊>The Journal of Nutrition: Official Organ of the American Institute of Nutrition >Plasma Ferritin and Soluble Transferrin Receptor Concentrations and Body Iron Stores Identify Similar Risk Factors for Iron Deficiency but Result in Different Estimates of the National Prevalence of Iron Deficiency and Iron-Deficiency Anemia among Women and Children in Cameroon
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Plasma Ferritin and Soluble Transferrin Receptor Concentrations and Body Iron Stores Identify Similar Risk Factors for Iron Deficiency but Result in Different Estimates of the National Prevalence of Iron Deficiency and Iron-Deficiency Anemia among Women and Children in Cameroon

机译：血浆铁蛋白和可溶性转铁蛋白受体浓度以及体内铁存储确定相似的铁缺乏风险因素，但导致喀麦隆妇女和儿童的全国铁缺乏和铁缺乏性贫血患病率的估计不同

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摘要

Available iron status indicators reflect different aspects of metabolism. We compared the prevalence and distribution of iron deficiency (ID) and iron-deficiency anemia (IDA) among Cameroonian women and children, as measured by plasma ferritin, and soluble transferrin receptor concentrations, body iron stores (BIS), and hemoglobin, and evaluated the impact of adjustments for inflammation on these measures. In a nationally representative survey, we randomly selected 30 clusters in each of 3 zones (north, south, and large cities) and 10 households/ cluster, each with a child aged 12–59 mo and a woman 15–49 y. Ferritin and BIS were mathematically adjusted for inflammation, using plasma C-reactive protein and α1-acid glycoprotein both as continuous and categorical variables. Inflammation was present in 48.0% of children and 20.8% of women and anemia was diagnosed in 57.6% of children and 38.8% of women. Depending on the iron status indicator applied, the prevalence of ID ranged from 14.2 to 68.4% among children and 11.5 to 31.8% among women, and the prevalence of IDA ranged from 12.0 to 47.4% among children and 9.0 to 19.4% among women; the proportion of anemia associated with ID ranged from 20.8 to 82.3% among children and 23.2 to 50.0% among women. The different iron indicators generally identified similar groups at greatest risk of deficiency, using both conventional and derived cutoffs: younger children, pregnant women, and women and children in the north and rural areas. Research is needed to clarify the relationships between iron status indicators, particularly in the presence of inflammation, to harmonize global data on prevalence of ID.
机译：可用的铁状态指标反映了新陈代谢的不同方面。我们比较了喀麦隆妇女和儿童中铁缺乏症（ID）和缺铁性贫血（IDA）的患病率和分布，通过血浆铁蛋白，可溶性转铁蛋白受体浓度，体内铁储备（BIS）和血红蛋白来衡量，并进行了评估炎症调整对这些措施的影响。在一项具有全国代表性的调查中，我们在3个区域（北部，南部和大城市）中的每个区域中随机选择了30个集群，每个集群有10个家庭，每个集群中有一个12-59岁的孩子和一个15-49岁的女人。使用血浆C反应蛋白和α1酸性糖蛋白作为连续变量和分类变量，对铁蛋白和BIS进行了炎症数学调节。在48.0％的儿童和20.8％的女性中存在炎症，在57.6％的儿童和38.8％的女性中诊断为贫血。根据所使用的铁质状况指标，儿童的ID患病率为14.2％至68.4％，妇女的ID患病率为11.5％至31.8％，儿童的IDA患病率为12.0％至47.4％，妇女的9.0％至19.4％;与ID相关的贫血比例在儿童中为20.8％至82.3％，在女性中为23.2％至50.0％。不同的铁指标通常使用常规和派生的临界值确定了出现最大风险的相似人群：年幼的孩子，孕妇以及北部和农村地区的妇女和儿童。需要进行研究以阐明铁状态指标之间的关系，尤其是在存在炎症的情况下，以协调有关ID患病率的全球数据。

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