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首页> 外文期刊>The Internet Journal of Toxicology >The Hepatotoxic Effects Of The Water-Soluble Fraction Of Spent Lubricating Oil In Wistar Albino Rats
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The Hepatotoxic Effects Of The Water-Soluble Fraction Of Spent Lubricating Oil In Wistar Albino Rats

机译：废润​​滑油的水溶性部分对Wistar白化病大鼠的肝毒性作用

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This aim of this study was to evaluate the hepatotoxic effects associated with pollution caused by spent lubricating oil, a major pollutant in Nigeria on terrestrial organisms. The hepatotoxic effects of three concentrations (10%, 50% and 100%) representing low, medium and high concentration of the water-soluble fraction (WSF) of spent lubricating oil in wistar albino rats was investigated. The range-finding test of WSF of spent lubricating oil was determined to be higher than 100% concentration after 48 hours. Serum L-alanine aminotransferase (L-ALT), L-aspartate amino transferase (L-AST), alkaline phosphatase (ALP) and lactate dehydrogenase (LDH) increased significantly (p≤ 0.05) after the administration of 2mL WSF of spent lubricating oil orally for 28 days. The order of increase was 100% >50% >10%. The WSF of spent lubricating oil was slightly acidic with a pH value of 6.7. Histopathological examination of the liver tissues revealed obliteration of sinusoids, macrovesicular fatty change, disorganized cords and enlargement of hepatocytes. The results suggest that oral administration of varying concentration of WSF of spent lubricating oil may cause an adverse effect on the function of the liver. Introduction The water-soluble fraction (WSF) constituents are dispersed particulate oil, dissolved hydrocarbon and soluble contaminants such as metallic ions??1.The components of spent lubricating oil that go into solution make up the WSF. They are taken up by living cells and are metabolized2. This is ecologically important because in event of an oil spill into aquatic habitat, this is absorbed by living organisms with serious effects on the ecosystem. Large amounts of spent lubricating oil are liberated into the environment when the motor oil is changed and disposed into gutters, water drains, open vacant plots and farmlands, a common practice by motor mechanics and generator mechanics3. The ubiquitous and pervasive nature of petroleum-derived hydrocarbons and the magnitude of their input to aquatic ecosystems are the two main motivating factors for research focused on their toxicity to terrestrial organisms. The fraction of oil that is most bioavailable to marine biota such as teleosts is the dissolved hydrocarbons, which include the polycyclic aromatic hydrocarbons (PAHs). The general importance of PAHs as a toxic component of petroleum-derived hydrocarbons is well established. Predicting the toxicity of these compounds is fraught with challenges, including dynamic chemical profiles, nonspecific and chemical- specific mechanisms of action, and variable intra- and inter species sensitivities. Moreover, because hydrocarbons from oil spills can persist in near-shore sediments for decades or longer4, investigations into toxicity need to incorporate long-term exposure regimes. The spent lubricating oil, otherwise called waste-lubricating oil or waste crankcase oil (WCO) obtained after servicing and subsequent draining from automobile, generators and industrial machines is disposed off indiscriminately, and adequate attention has not been given to its disposal5. Analytical procedures commonly used to assess contamination by petroleum products are determination of hydrocarbon fractions, total hydrocarbon and heavy metal contents. Edebiri and Nwanokwale6, reported that metals present in spent lubricating oil are not necessarily the same as those present in the unused lubricants. It has also been observed that most heavy metals like Va, Pb, Al, Ni and Fe that are below detection in unused lubricants oil gave high concentration values in used oil7. The disposal of spent lubricating oil into open vacant plots and farms, gutters and water drains is an environmental risk considering the water table in the South-South Region of Nigeria and shallow bore-holes dug to get water for domestic use 8. The suspected major soil contaminant/pollutant was spent lubricating oil from engines and other machinery. Oil in soil makes the soil condition becom
机译：这项研究的目的是评估与废润滑油（尼日利亚主要污染物对陆生生物）造成的污染相关的肝毒性作用。研究了三种浓度（10％，50％和100％）的低浓度，中浓度和高浓度的废润滑油在wistar白化病大鼠中的肝毒性作用。在48小时后，废润滑油的WSF测距试验确定为高于100％浓度。服用2mL废润滑油WSF后，血清L-丙氨酸氨基转移酶（L-ALT），L-天冬氨酸氨基转移酶（L-AST），碱性磷酸酶（ALP）和乳酸脱氢酶（LDH）显着增加（p≤0.05）口服28天。增加的顺序为100％> 50％> 10％。废润​​滑油的WSF为弱酸性，pH值为6.7。肝组织的组织病理学检查显示窦样闭塞，大泡脂肪改变，无序的脐带和肝细胞肿大。结果表明，口服施用不同浓度的废润滑油WSF可能对肝脏功能产生不利影响。引言水溶性馏分（WSF）成分是分散的颗粒油，溶解的碳氢化合物和可溶性污染物，例如金属离子?? 1。进入溶液的废润滑油的成分组成了WSF。它们被活细胞吸收并被代谢2。这在生态上很重要，因为一旦发生溢油泄漏到水生生境中，就会被生物体吸收，这会对生态系统造成严重影响。更换机油并将其丢弃到排水沟，排水沟，空旷的土地和农田中时，大量的废润滑油会释放到环境中，这是电机技工和发电机技工的一种常见做法3。石油衍生的碳氢化合物的普遍性和普遍性及其向水生生态系统的输入量是研究其对陆生生物毒性的两个主要诱因。海洋生物区系（例如硬骨鱼）最具生物利用度的那部分油是溶解的碳氢化合物，其中包括多环芳烃（PAH）。众所周知，PAHs作为石油衍生的烃类的有毒成分的一般重要性。预测这些化合物的毒性充满挑战，包括动态化学特征，非特异性和化学特异性作用机制以及物种内和物种间敏感性变化。此外，由于来自溢油的碳氢化合物可以在近岸沉积物中持续存在数十年或更长时间4，因此对毒性的研究需要纳入长期暴露制度。在维修后从汽车，发电机和工业机械中排出后得到的废润滑油，或称废润滑油或曲轴箱废油，被任意处置，未得到足够的重视5。通常用于评估石油产品污染的分析程序是确定烃馏分，总烃和重金属含量。 Edebiri和Nwanokwale6报告说，废润滑油中存在的金属不一定与未使用的润滑油中存在的金属相同。还已经观察到，在未使用的润滑油中检测不到的大多数重金属，如Va，Pb，Al，Ni和Fe，在废油中的浓度较高。考虑到尼日利亚南南地区的地下水位和为获取家用水而挖的浅孔，将用过的润滑油处置到空旷的空地，农场，排水沟和排水沟中是一种环境风险。8土壤污染物/污染物是来自发动机和其他机械的润滑油。土壤中的油使土壤状况恶化

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