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首页> 外文期刊>The Journal of Nutrition: Official Organ of the American Institute of Nutrition >Maternal–Infant Supplementation with Small-Quantity Lipid-Based Nutrient Supplements Does Not Affect Child Blood Pressure at 4–6 Y in Ghana: Follow-up of a Randomized Trial
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Maternal–Infant Supplementation with Small-Quantity Lipid-Based Nutrient Supplements Does Not Affect Child Blood Pressure at 4–6 Y in Ghana: Follow-up of a Randomized Trial

机译：母婴补充和少量脂类营养补充剂不会影响加纳4-6岁儿童血压：一项随机试验的随访结果

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ABSTRACT Background In the International Lipid-Based Nutrient Supplements (iLiNS)-DYAD-Ghana trial, prenatal small-quantity lipid-based nutrient supplements (LNSs) had a positive effect on birth weight. Birth weight may be inversely related to blood pressure (BP) later in life. Objectives We examined the effect of the intervention on BP at 4–6 y of age, and maternal and child factors related to BP. Methods The iLiNS-DYAD-Ghana study was a partially double-blind, randomized controlled trial which assigned women ( n ?=?1320) ≤20 weeks of gestation to daily supplementation with: 1 ) iron and folic acid during pregnancy and 200 mg Ca for 6 mo postpartum , 2 ) multiple micronutrients during pregnancy and postpartum, or 3 ) LNSs during pregnancy and postpartum plus LNSs for infants from 6 to 18 mo of age. At 4–6 y of age ( n ?=?858, 70% of live births), we compared BP, a secondary outcome, between non-LNS and LNS groups and examined whether BP was related to several factors including maternal BP, child weight-for-age z score (WAZ), and physical activity. Results Non-LNS and LNS groups did not differ in systolic (99.2?±?0.4 compared with 98.5?±?0.6 mm Hg; P ?=?0.317) or diastolic (60.1?±?0.3 compared with 60.0?±?0.4 mm Hg; P ?=?0.805) BP, or prevalence of high BP (systolic or diastolic BP ≥90th percentile of the US National Heart, Lung, and Blood Institute reference: 31% compared with 28%; P ?=?0.251). BP at 4–6 y of age was positively related to birth weight; this relation was largely mediated through concurrent WAZ in a path model. Concurrent WAZ and maternal BP were the factors most strongly related to child BP. Conclusions Despite greater birth weight in the LNS group, there was no intervention group difference in BP at 4–6 y. In this preschool population at high risk of adult hypertension based on BP at 4–6 y, high maternal BP and child WAZ were key factors related to BP. This trial was registered at clinicaltrials.gov as NCT00970866.
机译：摘要背景在国际基于脂质的营养补充剂（iLiNS）-DYAD-Ghana试验中，产前小量基于脂质的营养补充剂（LNSs）对出生体重有积极影响。出生体重在以后的生活中可能与血压（BP）成反比。目的我们研究了干预措施在4-6岁年龄段对BP的影响以及与BP相关的母婴因素。方法iLiNS-DYAD-Ghana研究是一项部分双盲，随机对照试验，该试验分配了≤20周妊娠的女性（n == 1320）每天补充：1）孕期铁和叶酸以及200 mg Ca对于产后6个月的婴儿，2）怀孕和产后的多种微量营养素，或3）怀孕和产后的LNS加6到18个月大的婴儿的LNS。在4-6岁（n == 858，占活产婴儿的70％）时，我们比较了非LNS组和LNS组之间的次要结果BP，并检查了BP是否与包括孕妇BP，儿童在内的几个因素相关年龄加权z得分（WAZ）和体育锻炼。结果非LNS组和LNS组的收缩压（99.2±±0.4 mm Hg，98.5±±0.6 mm Hg;P≥0.317）和舒张期（60.1±±0.3 0.3 60.0±±0.4 mm Hg）无差异。 Hg; P <= 0.805）BP，或高BP的患病率（收缩压或舒张BP≥美国国家心脏，血液和血液研究所参考值的90％：31％，而28％; P <= 0.251）。 4-6岁时的血压与出生体重呈正相关。这种关系主要是通过路径模型中的并发WAZ来调解的。并发的WAZ和母体BP是与儿童BP最相关的因素。结论尽管LNS组的出生体重增加，但干预组在4-6岁时的BP没有差异。在这个基于BP 4-6岁的成人高血压高危学龄前儿童中，高产妇BP和儿童WAZ是与BP相关的关键因素。该试验已在Clinicaltrials.gov上注册为NCT00970866。

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