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首页> 外文期刊>The Journal of Veterinary Medical Science >Pathological Studies on Cerebral Amyloid Angiopathy, Senile Plaques and Amyloid Deposition in Visceral Organs in Aged Dogs
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Pathological Studies on Cerebral Amyloid Angiopathy, Senile Plaques and Amyloid Deposition in Visceral Organs in Aged Dogs

机译：老年犬内脏器官中脑淀粉样血管病，老年斑和淀粉样沉积的病理学研究

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References(32) Cited-By(32) The relationship between cerebral lesions such as amyloid angiopathy or senile plaques and amyloid deposition in the visceral organs were studied in 90 autopsy cases of dogs, 0 to 19-year-old. Cerebral amyloid angiopathy was detected in 28 aged dogs (mean age: 13.7-year-old) and was found mostly in or around the wall of cerebral meningeal arterioles and capillaries of the neocortex. That condition was often accompanied by cerebral hemorrhage in dogs more than 9 years of age. Senile plaques were detected in the neocortex of the brain of 12 dogs (mean age: 13.2-year-old) and classified into 3 subtyped, i.e., "diffuse plaque", "primitive plaque" and "classical plaque". Among those 3 subtypes of senile plaques, amyloid containing plaques were small in number. In the visceral organs of dogs with cerebral amyloid angiopathy, amyloid deposition was found in the vascular walls or cornnective tissues of small intestines at a high frequency and sometimes in the vascular walls of the heart, lung, liver and thyroid gland as well as in atrioventricular valves. Amyloid in both cerebral and visceral organs was congophilic and showed green birefringence under poralized light even after potassium permanganate oxidation.
机译：参考文献（32）被引用的文献（32）研究了90例0至19岁狗的尸检病例，研究了诸如淀粉样血管病或老年斑等脑部病变与内脏器官淀粉样沉积之间的关系。在28只成年狗（平均年龄：13.7岁）中发现了脑淀粉样血管病，并且主要在大脑皮层和新皮层的毛细血管壁内或周围发现。在9岁以上的狗中，这种情况经常伴有脑出血。在12只狗（平均年龄：13.2岁）的大脑新皮质中检测到了老年斑，并将其分为3种亚型，即“弥散斑”，“原始斑”和“经典斑”。在这三种亚型的老年斑中，含淀粉样蛋白的斑块数量很少。在患有脑淀粉样血管病的狗的内脏器官中，淀粉样蛋白沉积频率很高，有时在小肠的血管壁或角膜移植组织中出现，有时在心脏，肺，肝和甲状腺的血管壁以及房室中发现阀门。即使在高锰酸钾氧化后，脑部和内脏器官中的淀粉样蛋白都具有亲血性，并且在口服光下仍显示绿色双折射。

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