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首页> 外文期刊>The Journal of Veterinary Medical Science >Preliminary Immunohistochemical Study of Natriuretic Peptide Receptor Localization in Canine and Feline Heart
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Preliminary Immunohistochemical Study of Natriuretic Peptide Receptor Localization in Canine and Feline Heart

机译：犬和​​猫心脏中利钠肽受体定位的初步免疫组织化学研究

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References(16) Cited-By(2) We examined the immunohistochemical distributions of natriuretic peptide receptor (NPR)-A, -B and -C that bind with natriuretic peptide hormones A, B and C in four healthy crossbreed young canine and feline cardiac tissues using specific antibodies against human antigens. Cross-immunoreactivities between antigens and antibodies were confirmed using western blot analysis. NPR-A and -C were expressed more strongly in dogs than cats. In both species, these expressions were stronger in the atria than the ventricles, with stronger expression in the left ventricles than the right. NPR-B was largely very weekly or undetected. In canine and feline cardiac tissues, the expressional distribution of NPR-A, -B, and -C closely matched with that of atrial natriuretic peptide, brain natriuretic peptide, and C-type natriuretic peptide as the ligands for corresponding receptors.
机译：参考文献（16）被引用的By（2）我们检查了利尿钠肽受体（NPR）-A，-B和-C与利尿钠肽激素A，B和C结合的四种健康杂种幼犬和猫心脏的免疫组织化学分布组织使用针对人类抗原的特异性抗体。使用蛋白质印迹分析确认了抗原和抗体之间的交叉免疫反应性。 NPR-A和-C在猫中比在猫中更强烈地表达。在这两个物种中，这些表达在心房中均比心室更强，在左心室中的表达强于右心室。 NPR-B在很大程度上是每周一次或未被发现。在犬和猫的心脏组织中，NPR-A，-B和-C的表达分布与心房利钠肽，脑利钠肽和C型利钠肽作为相应受体的配体紧密匹配。

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