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首页> 外文期刊>The Internet Journal of Toxicology >Accidental Ingestion of Venlafaxine in a 9 Month Old Infant
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Accidental Ingestion of Venlafaxine in a 9 Month Old Infant

机译：9个月大婴儿意外摄入文拉法辛

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Venlafaxine is a serotoninorepinephrine reuptake inhibitor approved for adults with depressive, panic, and anxiety disorders. The safety and efficacy of venlafaxine has not yet been adequately established in pediatric patients to allow approval although studies have been reported in children and adolescents with primarily attention-deficit hyperactivity disorder and depression. The intentional or unintentional use of venlafaxine in patients less than 3 years of age has not been extensively reported. OBJECTIVE: To report the adverse effects following the probable accidental ingestion of venlafaxine in a 9-month-old infant.CASE SUMMARY: The infant presented to the emergency department about 7 hours after a presumed ingestion of a single 150 mg venlafaxine extended-release capsule. His mother and grandmother described him as having a “drugged look”, trembling, shaking, pill-rolling with his tongue, dilated pupils, and other odd behaviors. Upon presentation to the emergency room, he was sedate, had dilated pupils, and had depressed mental status. His urine was positive for phencyclidine (PCP), but a confirmatory test could not be done due to mishandling of the specimen. He was admitted and observed throughout the night. He was acting and eating normally the following morning and was subsequently discharged in stable condition.CONCLUSIONS: There is minimal information regarding venlafaxine toxicity in infants and children but accidental ingestion may cause a variety of serotonergic, anticholinergic, and neuromuscular adverse effects, mental status changes, and autonomic instability. Supportive care is a reasonable treatment when symptoms are not severe.
机译：Venlafaxine是一种5-羟色胺/去甲肾上腺素再摄取抑制剂，被批准用于患有抑郁症，恐慌症和焦虑症的成年人。文拉法辛在儿童患者中的安全性和有效性尚未得到充分证实，尽管需要研究的儿童和青少年主要患有注意力缺陷多动障碍和抑郁症，但尚不能获得批准。尚未广泛报道在3岁以下患者中有意或无意使用文拉法辛。目的：报告可能意外摄入9个月大婴儿中的文拉法辛后的不良反应病例摘要：该婴儿在假定摄入150 mg文拉法辛缓释胶囊后约7小时出现在急诊科。 。他的母亲和祖母将他形容为“毒品的表情”，颤抖，发抖，用舌头滚动药丸，瞳孔散大以及其他奇怪行为。当他到急诊室就诊时，他很安静，瞳孔散大，精神状态低落。他的尿液中苯环利定（PCP）呈阳性，但由于处理不当而无法进行确认性测试。他被录取并整夜观察。结论：他对文拉法辛对婴儿和儿童的毒性了解很少，但意外摄入可能引起多种血清素能，抗胆碱能和神经肌肉不良反应，精神状态改变。和自主神经不稳定。当症状不严重时，支持治疗是一种合理的治疗方法。

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