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首页> 外文期刊>The Journal of Veterinary Medical Science >Morphological Observations of Megakaryocytic Emperipolesis in the Bone Marrow of Rats Treated with Lipopolysaccharide
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Morphological Observations of Megakaryocytic Emperipolesis in the Bone Marrow of Rats Treated with Lipopolysaccharide

机译：脂多糖治疗大鼠骨髓中巨核细胞体验性的形态学观察

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References(10) A morphological examination was performed on megakaryocytic emperipolesis containing neutrophils in the rat bone marrow induced by intravenous administration of lipopolysaccharide (LPS). Ultrastructurally, the engulfed neutrophils appeared to lie in the demarcation membrane system (DMS) of megakaryocytes. Intact neutrophils generally migrated from DMS into the lumen of vascular sinus across the endothelium of sinus wall. However, some neutrophils showed characteristics of apoptosis, and DNA fragmentation was detected in these cells by the terminal deoxynucleotidyl transferase (TdT)-mediated dUTP-biotin nick end labeling method. Thus, the cell death of neutrophils engulfed by megakaryocytes was thought to be apoptosis. The present results suggest that megakaryocytes contribute to random selection of an excess of neutrophils in the bone marrow of rats treated with LPS.
机译：参考文献（10）对通过静脉内注射脂多糖（LPS）诱导的大鼠骨髓中含有中性粒细胞的巨核细胞经验性进行了形态学检查。在超微结构上，吞噬的嗜中性粒细胞似乎位于巨核细胞的分界膜系统（DMS）中。完整的嗜中性粒细胞通常从DMS穿过窦壁内皮迁移到血管窦腔中。然而，一些嗜中性粒细胞显示出细胞凋亡的特征，并且通过末端脱氧核苷酸转移酶（TdT）介导的dUTP-生物素缺口末端标记法在这些细胞中检测到DNA片段化。因此，被巨核细胞吞噬的嗜中性白细胞的细胞死亡被认为是凋亡。目前的结果表明，巨核细胞有助于在接受LPS治疗的大鼠的骨髓中随机选择过量的嗜中性白细胞。

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