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首页> 外文期刊>The Korean Journal of Physiology & Pharmacology >Effects of rosmarinic acid on immunoregulatory activity and hepatocellular carcinoma cell apoptosis in H22 tumor-bearing mice
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Effects of rosmarinic acid on immunoregulatory activity and hepatocellular carcinoma cell apoptosis in H22 tumor-bearing mice

机译：迷迭香酸对H22荷瘤小鼠免疫调节活性和肝癌细胞凋亡的影响

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摘要

Rosmarinic acid (RA) is a natural polyphenolic compound that exists in many medicinal species of Boraginaceae and Lamiaceae . The previous studies have revealed that RA had therapeutic effects on hepatocellular carcinoma (HCC) in the H22 -xenograft models by inhibiting the inflammatory cytokines and NF-κB p65 pathway in the tumor microenvironment. However, its molecular mechanisms of immunoregulation and pro-apoptotic effect in HCC have not been fully explored. In the present study, RA at 75, 150, and 300 mg/kg was given to H22 tumor-bearing mice via gavage once a day for 10 days. The results showed that RA can effectively inhibit the tumor growth through regulating the ratio of CD4sup+/sup/CD8sup+/sup and the secretion of interleukin (IL)-2 and interferon-γ, inhibiting the expressions of IL-6, IL-10 and signal transducer and activator of transcription 3, thereby up-regulating Bax and Caspase-3 and down-regulating Bcl-2 . The underlying mechanisms involved regulation of immune response and induction of HCC cell apoptosis. These results may provide a more comprehensive perspective to clarify the anti-tumor mechanism of RA in HCC.
机译：迷迭香酸（RA）是天然的多酚化合物，存在于紫草科和唇形科的许多药用物种中。先前的研究表明，RA通过抑制肿瘤微环境中的炎性细胞因子和NF-κBp65途径，在H22异种移植模型中对肝细胞癌（HCC）具有治疗作用。然而，其在肝癌中的免疫调节和促凋亡作用的分子机制尚未得到充分探索。在本研究中，每天分别通过强饲法将75、150和300 mg / kg的RA喂给H22荷瘤小鼠，持续10天。结果表明，RA可以通过调节CD4 + / CD8 + 的比例以及白介素（IL）-2和干扰素-γ的分泌来有效抑制肿瘤的生长，抑制IL-6，IL-10和信号转导和转录激活因子3的表达，从而上调Bax和Caspase-3并下调Bcl-2。潜在的机制涉及免疫应答的调节和HCC细胞凋亡的诱导。这些结果可能为阐明RA在肝癌中的抗肿瘤机制提供更全面的视角。

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