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首页> 外文期刊>The Korean Journal of Physiology & Pharmacology >Effect of Lutein on L-NAME-Induced Hypertensive Rats
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Effect of Lutein on L-NAME-Induced Hypertensive Rats

机译：叶黄素对L-NAME诱导的高血压大鼠的作用

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摘要

We investigated the antihypertensive effect of lutein on NG -nitro-L-arginine methyl ester hydrochloride (L-NAME)-induced hypertensive rats. Daily oral administration of L-NAME (40 mg/kg)-induced a rapid progressive increase in mean arterial pressure (MAP). L-NAME significantly increased MAP from the first week compared to that in the control and reached 193.3±9.6 mmHg at the end of treatment. MAP in the lutein groups was dose-dependently lower than that in the L-NAME group. Similar results were observed for systolic and diastolic blood pressure of L-NAME-induced hypertensive rats. The control group showed little change in heart rate for 3 weeks, whereas L-NAME significantly reduced heart rate from 434±26 to 376±33 beats/min. Lutein (2 mg/kg) significantly prevented the reduced heart rate induced by L-NAME. L-NAME caused hypertrophy of heart and kidney, and increased plasma lipid peroxidation four-fold but significantly reduced plasma nitrite and glutathione concentrations, which were significantly prevented by lutein in a dose-dependent manner. These findings suggest that lutein affords significant antihypertensive and antioxidant effects against L-NAME-induced hypertension in rats.
机译：我们研究了叶黄素对N G -硝基-L-精氨酸甲酯盐酸盐（L-NAME）诱导的高血压大鼠的降压作用。每天口服L-NAME（40 mg / kg）会导致平均动脉压（MAP）迅速逐步升高。与对照组相比，第一周的L-NAME显着提高了MAP，在治疗结束时达到了193.3±9.6 mmHg。叶黄素组的MAP剂量依赖性低于L-NAME组。对于L-NAME诱导的高血压大鼠的收缩压和舒张压观察到相似的结果。对照组在3周内心率变化不大，而L-NAME则将心率从434±26次/分显着降低至376±33次/分。叶黄素（2 mg / kg）显着阻止了L-NAME引起的心率降低。 L-NAME导致心脏和肾脏肥大，血浆脂质过氧化作用增加了四倍，但血浆亚硝酸盐和谷胱甘肽的浓度却明显降低，而叶黄素以剂量依赖的方式可以有效地防止血浆中亚硝酸盐和谷胱甘肽的浓度。这些发现表明，叶黄素对L-NAME诱导的高血压具有明显的降压和抗氧化作用。

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