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首页> 外文期刊>The Korean Journal of Physiology & Pharmacology >Anti-Oxidative and Anti-Inflammatory Effects of QGC in Cultured Feline Esophageal Epithelial Cells
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Anti-Oxidative and Anti-Inflammatory Effects of QGC in Cultured Feline Esophageal Epithelial Cells

机译：QGC对猫食管上皮细胞的抗氧化和抗炎作用

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摘要

Quercetin-3-O-β-D-glucuronopyranoside (QGC) is a flavonoid glucoside extracted from Rumex Aquaticus Herba . In the present study, anti-oxidative and anti-inflammatory effects of QGC were tested in vitro. Epithelial cells obtained from cat esophagus were cultured. When the cells were exposed to acid for 2 h, cell viability was decreased to 36%. Pretreatment with 50 μM QGC for 2 h prevented the reduction in cell viability. QGC also inhibited the productions of intracellular ROS by inflammatory inducers such as acid, lipopolysaccharide, indomethacin and ethanol. QGC significantly increased the activities of superoxide dismutase (SOD) and catalase, and also induced the expression of SOD2, while it restored the decrease of catalase expression in cells exposed to acid. QGC inhibited NF-κB translocation, cyclooxygenase-2 expression and PGE2 secretion in cells exposed to acid, which plays an important role in the pathogenesis of esophagitis. The data suggest that QGC may well be one of the promising substances to attenuate oxidative epithelial cell injury and inflammatory signaling in esophagus inflammation.
机译：槲皮素-3-O-β-D-葡萄糖醛酸吡喃糖苷（QGC）是从Rumex Aquaticus Herba中提取的类黄酮糖苷。在本研究中，体外测试了QGC的抗氧化和抗炎作用。培养从猫食管获得的上皮细胞。当细胞暴露于酸中2小时后，细胞活力降低至36％。用50μMQGC预处理2小时可防止细胞活力降低。 QGC还通过诸如酸，脂多糖，消炎痛和乙醇的炎症诱导剂抑制细胞内ROS的产生。 QGC显着增加了超氧化物歧化酶（SOD）和过氧化氢酶的活性，并诱导了SOD2的表达，同时它还恢复了暴露于酸的细胞中过氧化氢酶表达的下降。 QGC抑制酸性细胞中NF-κB的移位，环氧合酶-2的表达和PGE 2 的分泌，在食管炎的发病过程中起重要作用。数据表明，QGC可能是减轻食管炎症中氧化上皮细胞损伤和炎症信号的有前途的物质之一。

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