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首页> 外文期刊>The Korean Journal of Physiology & Pharmacology >Role of Nucleotide-binding and Oligomerization Domain 2 Protein (NOD2) in the Development of Atherosclerosis
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Role of Nucleotide-binding and Oligomerization Domain 2 Protein (NOD2) in the Development of Atherosclerosis

机译：核苷酸结合和寡聚化域2蛋白（NOD2）在动脉粥样硬化发展中的作用

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NOD2 (nucleotide-binding and oligomerization domain 2) was initially reported as a susceptibility gene for Crohn's disease, with several studies focused on elucidating its molecular mechanism in the progression of Crohn's disease. We now know that NOD2 is an intracellular bacterial sensing receptor, and that MDP-mediated NOD2 activation drives inflammatory signaling. Various mutations in NOD2 have been reported, with NOD2 loss of function being associated with the development of Crohn's disease and other autoimmune diseases. These results suggest that NOD2 not only has an immune stimulatory function, but also an immune regulatory function. Atherosclerosis is a chronic inflammatory disease of the arterial wall; its pathologic progression is highly dependent on the immune balance. This immune balance is regulated by infiltrating monocytes and macrophages, both of which express NOD2. These findings indicate a potential role of NOD2 in atherosclerosis. The purpose of this review is to outline the known roles of NOD2 signaling in the pathogenesis of atherosclerosis.
机译：最初报道了NOD2（核苷酸结合和寡聚域2）是克罗恩氏病的易感基因，一些研究致力于阐明其在克罗恩氏病进展中的分子机制。现在我们知道，NOD2是一种细胞内细菌感应受体，并且MDP介导的NOD2激活驱动炎症信号传导。已经报道了NOD2中的各种突变，其中NOD2功能的丧失与克罗恩氏病和其他自身免疫性疾病的发展有关。这些结果表明，NOD2不仅具有免疫刺激功能，而且具有免疫调节功能。动脉粥样硬化是一种动脉壁的慢性炎性疾病。其病理进展高度依赖于免疫平衡。这种免疫平衡通过浸润都表达NOD2的单核细胞和巨噬细胞来调节。这些发现表明NOD2在动脉粥样硬化中的潜在作用。这篇综述的目的是概述NOD2信号在动脉粥样硬化发病机理中的已知作用。

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