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首页> 外文期刊>The Korean Journal of Physiology & Pharmacology >Long-term Follow-up of Cutaneous Hypersensitivity in Rats with a Spinal Cord Contusion
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Long-term Follow-up of Cutaneous Hypersensitivity in Rats with a Spinal Cord Contusion

机译：脊髓挫伤大鼠皮肤超敏反应的长期随访

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Sometimes, spinal cord injury (SCI) results in various chronic neuropathic pain syndromes that occur diffusely below the level of the injury. It has been reported that behavioral signs of neuropathic pain are expressed in the animal models of contusive SCI. However, the observation period is relatively short considering the natural course of pain in human SCI patients. Therefore, this study was undertaken to examine the time course of mechanical and cold allodynia in the hindpaw after a spinal cord contusion in rats for a long period of time (30 weeks). The hindpaw withdrawal threshold to mechanical stimulation was applied to the plantar surface of the hindpaw, and the withdrawal frequency to the application of acetone was measured before and after a spinal contusion. The spinal cord contusion was produced by dropping a 10 g weight from a 6.25 and 12.5 mm height using a NYU impactor. After the injury, rats showed a decreased withdrawal threshold to von Frey stimulation, indicating the development of mechanical allodynia which persisted for 30 weeks. The withdrawal threshold between the two experimental groups was similar. The response frequencies to acetone increased after the SCI, but they were developed slowly. Cold allodynia persisted for 30 weeks in 12.5 mm group. The sham animals did not show any significant behavioral changes. These results provide behavioral evidence to indicate that the below-level pain was well developed and maintained in the contusion model for a long time, suggesting a model suitable for pain research, especially in the late stage of SCI or for long term effects of analgesic intervention.
机译：有时，脊髓损伤（SCI）会导致多种慢性神经性疼痛综合征，并在损伤程度以下广泛扩散。据报道，在挫伤性脊髓损伤的动物模型中表达了神经性疼痛的行为迹象。但是，考虑到人类SCI患者的自然疼痛过程，观察期相对较短。因此，本研究旨在检查大鼠脊髓挫伤后很长一段时间（30周）后爪机械性和冷性异常性疼痛的时程。将机械刺激的后爪退出阈值施加到后爪的足底表面，并测量脊髓挫伤前后施加丙酮的退出频率。脊髓挫伤是通过使用NYU撞击器从6.25和12.5毫米高处掉落10克重物而产生的。受伤后，大鼠对冯·弗雷刺激的戒断阈值降低，这表明机械性异常性疼痛的发展持续了30周。两个实验组之间的戒断阈值相似。 SCI后，对丙酮的响应频率增加，但发展缓慢。 12.5 mm组冷性异常性疼痛持续30周。假动物没有表现出任何明显的行为变化。这些结果提供了行为证据，表明在长期以来挫伤模型中很好地发展和维持了低于水平的疼痛，这表明该模型适用于疼痛研究，尤其是在SCI的晚期或镇痛干预的长期作用。

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