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首页> 外文期刊>The Korean Journal of Physiology & Pharmacology >Temporal Changes of the Calcium-binding Proteins in the Medial Vestibular Nucleus following Unilateral Labyrinthectomy in Rats
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Temporal Changes of the Calcium-binding Proteins in the Medial Vestibular Nucleus following Unilateral Labyrinthectomy in Rats

机译：大鼠单侧迷路切除术后内侧前庭核中钙结合蛋白的时间变化

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摘要

Calcium (Ca2+) is an intracellular second messenger associated with neuronal plasticity of the central nervous system. The calcium-binding proteins regulate the Ca2+-mediated signals in the cytoplasm and buffer the calcium concentration. This study examined temporal changes of three calcium-binding proteins (calretinin, calbindin and parvalbumin) in the medial vestibular nucleus (MVN) during vestibular compensation after unilateral labyrinthectomy (UL) in rats. Rats underwent UL, and the changes in the expression of these proteins at 2, 6, 12, 24, 48, and 72 h were examined by immunofluorescence staining. The expression levels of all three proteins increased immediately after UL and returned to the control level by 48 h. However, the level of calretinin showed changes different from the other two proteins, being expressed at significantly higher level in the contralateral MVN than in the ipsilateral MVN 2 h after UL, whereas the other two proteins showed similar expression levels in both the ipsilateral and contralateral MVN. These results suggest that the calcium binding proteins have some protective activity against the increased Ca2+ levels in the MVN. In particular, calretinin might be more responsive to neuronal activity than calbindin or parvalbumin.
机译：钙（Ca 2 + ）是与中枢神经系统神经元可塑性相关的细胞内第二信使。钙结合蛋白调节细胞质中Ca 2 + 介导的信号并缓冲钙浓度。这项研究检查了大鼠单侧迷路切除术（UL）前庭补偿期间，前庭内侧核（MVN）中三种钙结合蛋白（calretinin，calbindin和parvalbumin）的时间变化。大鼠经历了UL，并且在2、6、12、24、48和72小时通过免疫荧光染色检查了这些蛋白的表达变化。 UL后，所有三种蛋白质的表达水平立即增加，并在48小时后恢复到对照水平。然而，钙调蛋白的水平显示出与其他两种蛋白不同的变化，在UL后2 h，对侧MVN中的表达水平明显高于同侧MVN，而其他两种蛋白在对侧和对侧的表达水平相似MVN。这些结果表明钙结合蛋白对MVN中Ca 2 + 水平的升高具有一定的保护作用。特别是，钙调蛋白可能比钙调蛋白或小白蛋白对神经元活动更敏感。

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