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首页> 外文期刊>The Korean Journal of Physiology & Pharmacology >Association between Interleukin 31 Receptor A Gene Polymorphism and Schizophrenia in Korean Population
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Association between Interleukin 31 Receptor A Gene Polymorphism and Schizophrenia in Korean Population

机译：白细胞介素31受体A基因多态性与朝鲜族精神分裂症的关系

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Recently, Sun et al ( 2008 ) reported that the IL6R polymorphism is associated with schizophrenia. Therefore, to detect the association between polymorphisms of interleukin 31 receptor A (IL31RA) and schizophrenia, we genotyped 9 SNPs [rs9292101 (intron 1), rs1009639 (exon 2, Pro43Pro), rs2161582 (intron 2), rs68761890 (intron 5), rs16884629 (intron 6), rs11956465 (intron 12), rs12153724 (intron 12), and rs16884641 (intron 14)] using the Golden Gate assay on Illumina BeadStation 500 GX. Two hundred eighteen patients with schizophrenia and 379 normal subjects were recruited. Patients with schizophrenia were diagnosed according to DSM-IV, and control subjects without history of psychiatric disorders were selected. We used SNPStats, Haploview, HapAnalyzer, SNPAnalyzer, and Helixtree programs for the evaluation of genetic data. Of nine polymorphisms, three SNPs (rs9292101, rs1009639, and rs11956465) were associated with schizophrenia. The rs9292101 and rs11956465 showed significant associations with the risk of schizophrenia in the codominant [rs9292101, odds ratio (OR)=0.74, 95% confidence interval (CI)=0.58~0.95, p=0.017] and recessive (rs11956465, OR=0.64, 95% CI=0.42~0.96, p=0.034) models, respectively. The rs1009639 also was statistically related to schizophrenia in both codominant (OR=0.76, 95% CI=0.60~0.97, p=0.025) and dominant (OR=0.66, 95% CI=0.44~0.98, p=0.035) models. Two linkage disequilibrium (LD) blocks were made. In the analysis of haplotypes, a haplotype (GCT) in block 1 and a haplotype (CCACAG) in block 2 showed significant associations between schizophrenia and control groups (haplotype GCT, frequency=0.509, chi square=4.199, p=0.040; haplotype CCACAG, frequency=0.289, chi square=5.691, p=0.017). The results suggest that IL31RA may be associated with risk of schizophrenia in Korean population.
机译：最近，Sun等人（2008）报道IL6R多态性与精神分裂症有关。因此，为检测白介素31受体A（IL31RA）多态性与精神分裂症之间的关联，我们对9个SNP进行了基因分型[rs9292101（内含子1），rs1009639（外显子2，Pro43Pro），rs2161582（内含子2），rs68761890（内含子5）， rs16884629（内含子6），rs11956465（内含子12），rs12153724（内含子12）和rs16884641（内含子14）]在Illumina BeadStation 500 GX上进行金门检测。招募了218名精神分裂症患者和379名正常受试者。根据DSM-IV诊断为精神分裂症患者，并选择无精神病史的对照对象。我们使用SNPStats，Haploview，HapAnalyzer，SNPAnalyzer和Helixtree程序评估遗传数据。在9个多态性中，三个SNP（rs9292101，rs1009639和rs11956465）与精神分裂症相关。 rs9292101和rs11956465与共患精神分裂症的风险显着相关[rs9292101，优势比（OR）= 0.74，95％置信区间（CI）= 0.58〜0.95，p = 0.017]和隐性（rs11956465，OR = 0.64） ，95％CI = 0.42〜0.96，p = 0.034）模型。 rs1009639在共显性（OR = 0.76，95％CI = 0.60〜0.97，p = 0.025）和显性（OR = 0.66，95％CI = 0.44〜0.98，p = 0.035）模型中也与精神分裂症有统计学意义。制备了两个连锁不平衡（LD）嵌段。在单倍型分析中，第1区块的单倍型（GCT）和第2区块的单倍型（CCACAG）显示精神分裂症与对照组之间存在显着关联（单倍型GCT，频率= 0.509，卡方= 4.199，p = 0.040;单倍型CCACAG ，频率= 0.289，卡方= 5.691，p = 0.017）。结果表明IL31RA可能与韩国人群的精神分裂症风险有关。

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