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首页> 外文期刊>The Korean Journal of Physiology & Pharmacology >Glycyrrhizin Attenuates MPTP Neurotoxicity in Mouse and MPP+-Induced Cell Death in PC12 Cells
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Glycyrrhizin Attenuates MPTP Neurotoxicity in Mouse and MPP+-Induced Cell Death in PC12 Cells

机译：甘草甜素减轻小鼠的MPTP神经毒性和PC12细胞中MPP +诱导的细胞死亡。

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The present study examined the inhibitory effect of licorice compounds glycyrrhizin and a metabolite 18β-glycyrrhetinic acid on the neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in the mouse and on the 1-methyl-4-phenylpyridinium (MPP+)-induced cell death in differentiated PC12 cells. MPTP treatment increased the activities of total superoxide dismutase, catalase and glutathione peroxidase and the levels of malondialdehyde and carbonyls in the brain compared to control mouse brain. Co-administration of glycyrrhizin (16.8 mg/kg) attenuated the MPTP effect on the enzyme activities and formation of tissue peroxidation products. In vitro assay, licorice compounds attenuated the MPP+-induced cell death and caspase-3 activation in PC12 cells. Glycyrrhizin up to 100μM significantly attenuated the toxicity of MPP+. Meanwhile, 18β-glycyrrhetinic acid showed a maximum inhibitory effect at 10μM; beyond this concentration the inhibitory effect declined. Glycyrrhizin and 18β-glycyrrhetinic acid attenuated the hydrogen peroxide- or nitrogen species-induced cell death. Results from this study indicate that glycyrrhizin may attenuate brain tissue damage in mice treated with MPTP through inhibitory effect on oxidative tissue damage. Glycyrrhizin and 18β-glycyrrhetinic acid may reduce the MPP+ toxicity in PC12 cells by suppressing caspase-3 activation. The effect seems to be ascribed to the antioxidant effect.
机译：本研究研究了甘草化合物甘草甜素和代谢产物18β-甘草次酸对1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）对小鼠和1-小鼠神经毒性的抑制作用。甲基-4-苯基吡啶鎓（MPP + ）诱导分化的PC12细胞死亡。与对照小鼠大脑相比，MPTP处理可增加大脑中总超氧化物歧化酶，过氧化氢酶和谷胱甘肽过氧化物酶的活性以及丙二醛和羰基的水平。甘草甜素（16.8 mg / kg）的共同给药减弱了MPTP对酶活性和组织过氧化产物形成的影响。在体外测定中，甘草化合物可减轻MPP + 诱导的PC12细胞死亡和caspase-3活化。高达100μM的甘草甜素可显着降低MPP + 的毒性。同时，18β-甘草次酸在10μM时表现出最大的抑制作用。超过该浓度，抑制作用下降。甘草甜素和18β-甘草次酸减弱了过氧化氢或氮物种诱导的细胞死亡。这项研究的结果表明，甘草甜素可能通过对氧化性组织损伤的抑制作用来减轻MPTP处理的小鼠的脑组织损伤。甘草甜素和18β-甘草次酸可通过抑制caspase-3活化来降低PC12细胞的MPP + 毒性。该作用似乎归因于抗氧化剂作用。

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