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首页> 外文期刊>The Korean Journal of Physiology & Pharmacology >Role of Glucocorticoids in Fasting-induced Changes in Hypothalamic and Pituitary Components of the Growth Hormone (GH)-axis
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Role of Glucocorticoids in Fasting-induced Changes in Hypothalamic and Pituitary Components of the Growth Hormone (GH)-axis

机译：糖皮质激素在空腹诱导的生长激素（GH）轴下丘脑和垂体成分变化中的作用

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To directly test if elevated glucocorticoids are required for fasting-induced regulation of growth hormone (GH)-releasing hormone (GHRH), GHRH receptors (GHRH-R) and ghrelin receptors (GHS-R) expression, male rats were bilaterally adrenalectomized or sham operated. After 7 days, animals were fed ad libitum or fasted for 48 h. Bilateral adrenalectomy increased hypothalamic GHRH to 146% and decreased neuropeptide Y (NPY) mRNA to 54% of SHAM controls. Pituitary GHRH-R and GHS-R mRNA levels were decreased by adrenalectomy to 30% and 80% of sham-operated controls. In shamoperated rats, fasting suppressed hypothalamic GHRH (49%) and stimulated NPY (166%) mRNA levels, while fasting increased pituitary GHRH-R (391%) and GHS-R (218%) mRNA levels. However, in adrenalectomized rats, fasting failed to alter pituitary GHRH-R mRNA levels, while the fasting-induced suppression of GHRH and elevation of NPY and GHS-R mRNA levels remained intact. In fasted adrenalectomized rats, corticosterone replacement increased GHRH-R mRNA levels and intensified the fasting-induced decrease in GHRH, but did not alter NPY or GHS-R response. These data suggest that elevated glucocorticoids mediate the effects of fasting on hypothalamic GHRH and pituitary GHRH-R expression, while glucocorticoids are likely not the major determinant in fasting-induced increases in hypothalamic NPY and pituitary GHS-R expression.
机译：为了直接测试是否需要空腹糖皮质激素升高来禁食诱导调节生长激素（GH）释放激素（GHRH），GHRH受体（GHRH-R）和ghrelin受体（GHS-R）的表达，对雄性大鼠进行了双边肾上腺切除术或假手术经营。 7天后，随意喂养动物或禁食48小时。双侧肾上腺切除术将下丘脑GHRH增加到146％，而神经肽Y（NPY）mRNA减少到SHAM对照的54％。肾上腺切除术可将垂体GHRH-R和GHS-R mRNA水平降低至假手术对照组的30％和80％。在假手术的大鼠中，禁食可抑制下丘脑GHRH（49％）并刺激NPY（166％）mRNA水平，而禁食可增加垂体GHRH-R（391％）和GHS-R（218％）mRNA水平。然而，在肾上腺切除的大鼠中，禁食未能改变垂体GHRH-R mRNA水平，而禁食诱导的GHRH抑制以及NPY和GHS-R mRNA水平升高仍保持完整。在禁食的肾上腺切除大鼠中，皮质酮替代增加了GHRH-R mRNA水平，并增强了禁食引起的GHRH下降，但并未改变NPY或GHS-R反应。这些数据表明，糖皮质激素升高介导了禁食对下丘脑GHRH和垂体GHRH-R表达的影响，而糖皮质激素可能不是空腹诱导下丘脑NPY和垂体GHS-R表达增加的主要决定因素。

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