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首页> 外文期刊>The Korean Journal of Physiology & Pharmacology >Anti-inflammatory, Antioxidant and Antimicrobial Effects of Artemisinin Extracts from Artemisia annua L.
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Anti-inflammatory, Antioxidant and Antimicrobial Effects of Artemisinin Extracts from Artemisia annua L.

机译：青蒿中青蒿素提取物的抗炎，抗氧化和抗菌作用

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摘要

The anti-inflammatory, antioxidant, and antimicrobial properties of artemisinin derived from water, methanol, ethanol, or acetone extracts of Artemisia annua L. were evaluated. All 4 artemisinin-containing extracts had anti-inflammatory effects. Of these, the acetone extract had the greatest inhibitory effect on lipopolysaccharide-induced nitric oxide (NO), prostaglandin E2 (PGE2), and proinflammatory cytokine (IL-1β , IL-6, and IL-10) production. Antioxidant activity evaluations revealed that the ethanol extract had the highest free radical scavenging activity, (91.0±3.2%), similar to α-tocopherol (99.9%). The extracts had antimicrobial activity against the periodontopathic microorganisms Aggregatibacter actinomycetemcomitans , Fusobacterium nucleatum subsp. animalis , Fusobacterium nucleatum subsp. polymorphum , and Prevotella intermedia . This study shows that Artemisia annua L. extracts contain anti-inflammatory, antioxidant, and antimicrobial substances and should be considered for use in pharmaceutical products for the treatment of dental diseases.
机译：对青蒿素衍生自青蒿的水，甲醇，乙醇或丙酮提取物的抗炎，抗氧化和抗菌性能进行了评估。所有4种含青蒿素的提取物均具有抗炎作用。其中，丙酮提取物对脂多糖诱导的一氧化氮（NO），前列腺素E 2 （PGE 2 ）和促炎细胞因子（IL-1β）的抑制作用最大。 ，IL-6和IL-10）生产。抗氧化活性评估表明，乙醇提取物具有最高的自由基清除活性（91.0±3.2％），类似于α-生育酚（99.9％）。提取物对牙周病微生物聚集性放线菌，核梭菌亚种具有抗菌活性。动物群，核梭菌亚种多形体和中间肠杆菌。这项研究表明，青蒿提取物含有抗炎，抗氧化剂和抗菌物质，应考虑将其用于治疗牙齿疾病的药品中。

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