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首页> 外文期刊>The Korean Journal of Physiology & Pharmacology >Androgen Receptor-dependent Expression of Low-density Lipoprotein Receptor-related Protein 6 is Necessary for Prostate Cancer Cell Proliferation
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Androgen Receptor-dependent Expression of Low-density Lipoprotein Receptor-related Protein 6 is Necessary for Prostate Cancer Cell Proliferation

机译：低密度脂蛋白受体相关蛋白6的雄激素受体依赖性表达是前列腺癌细胞增殖所必需的

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摘要

Androgen receptor (AR) signaling is important for prostate cancer (PCa) cell proliferation. Here, we showed that proliferation of hormone-sensitive prostate cancer cells such as LNCaP was significantly enhanced by testosterone stimulation whereas hormone-insensitive prostate cancer cells such as PC3 and VCaP did not respond to testosterone stimulation. Blocking of AR using bicalutamide abolished testosterone-induced proliferation of LNCaP cells. In addition, knockdown of AR blocked testosterone-induced proliferation of LNCaP cells. Basal expression of low-density lipoprotein receptor-related protein 6 (LRP6) was elevated in VCaP cells whereas stimulation of testosterone did not affect the expression of LRP6. However, expression of LRP6 in LNCaP cells was increased by testosterone stimulation. In addition, knockdown of LRP6 abrogated testosterone-induced proliferation of LNCaP cells. Given these results, we suggest that androgen-dependent expression of LRP6 plays a crucial role in hormone-sensitive prostate cancer cell proliferation.
机译：雄激素受体（AR）信号对于前列腺癌（PCa）细胞增殖很重要。在这里，我们显示了睾丸激素刺激显着增强了激素敏感性前列腺癌细胞如LNCaP的增殖，而激素敏感性前列腺癌细胞如PC3和VCaP对睾丸激素刺激没有反应。使用比卡鲁胺阻断AR消除了睾丸激素诱导的LNCaP细胞增殖。另外，AR的敲低阻断了睾丸激素诱导的LNCaP细胞的增殖。低密度脂蛋白受体相关蛋白6（LRP6）的基础表达在VCaP细胞中升高，而睾丸激素的刺激并不影响LRP6的表达。然而，通过睾丸激素刺激，LNCaP细胞中LRP6的表达增加。此外，LRP6的敲除废除了睾丸激素诱导的LNCaP细胞增殖。鉴于这些结果，我们建议LRP6的雄激素依赖性表达在激素敏感性前列腺癌细胞增殖中起关键作用。

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