Metabotropic glutamate receptor dependent long-term depression in the cortex

Kang Sukjae Joshua; Kaang Bong-Kiun

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Metabotropic glutamate receptor dependent long-term depression in the cortex

机译：代谢型谷氨酸受体依赖性皮层的长期抑制

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Metabotropic glutamate receptor (mGluR)-dependent long-term depression (LTD), a type of synaptic plasticity, is characterized by a reduction in the synaptic response, mainly at the excitatory synapses of the neurons. The hippocampus and the cerebellum have been the most extensively studied regions in mGluR-dependent LTD, and Group 1 mGluR has been reported to be mainly involved in this synaptic LTD at excitatory synapses. However, mGluR-dependent LTD in other brain regions may be involved in the specific behaviors or diseases. In this paper, we focus on five cortical regions and review the literature that implicates their contribution to the pathogenesis of several behaviors and specific conditions associated with mGluR-dependent LTD.

机译：代谢型谷氨酸受体（mGluR）依赖性长期抑郁症（LTD）是一种突触可塑性，其特征是突触反应减少，主要是在神经元的兴奋性突触处。海马和小脑是mGluR依赖型LTD中研究最广泛的区域，据报道第1组mGluR在兴奋性突触中主要参与该突触LTD。但是，其他大脑区域的mGluR依赖型LTD可能参与了特定的行为或疾病。在本文中，我们集中于五个皮质区域，并回顾了涉及它们对与mGluR依赖的LTD相关的几种行为和特定条件的发病机制的影响的文献。

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《The Korean Journal of Physiology & Pharmacology》 |2016年第6期|共8页
作者
Kang Sukjae Joshua; Kaang Bong-Kiun;
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1. Induction of NMDA receptor-dependent long-term depression in visual cortex does not require metabotropic glutamate receptors. [J] . Sawtell NB, Huber KM, Roder JC, Journal of Neurophysiology . 1999,第6期

机译：在视皮层中诱导NMDA受体依赖性长期抑制不需要代谢型谷氨酸受体。
2. Synaptically stimulated induction of group i metabotropic glutamate receptor-dependent long-term depression and depotentiation is inhibited by prior activation of metabotropic glutamate receptors and PROTEIN KINASE C. [J] . Wu J, Rowan MJ, Anwyl R Neuroscience: An International Journal under the Editorial Direction of IBRO . 2004,第2期

机译：突触谷氨酸受体和蛋白激酶C的事先激活抑制了突触刺激的组i代谢型谷氨酸受体依赖性长期抑制和去势。
3. Plasticity of metabotropic glutamate receptor-dependent long-term depression in the anterior cingulate cortex after amputation [J] . KangS.J., LiuM.-G., ChenT., The Journal of Neuroscience: The Official Journal of the Society for Neuroscience . 2012,第33期

机译：截肢后前扣带回皮质中代谢型谷氨酸受体依赖性长期抑制的可塑性
4. Manifold learning visualization of Metabotropic Glutamate Receptors [C] . Martha-Ivon Cardenas, Alfredo Vellido, Jesus Giraldo International Conference of the Catalan Association for Artificial Intelligence . 2014

机译：代谢谷氨酸受体的歧管学习可视化
5. The functional roles of metabotropic glutamate receptors in prefrontal cortex and the implications in Alzheimer's disease. [D] . Tyszkiewicz, Joanna P. 2006

机译：代谢型谷氨酸受体在前额叶皮层中的功能作用及其在阿尔茨海默氏病中的意义。
6. Experience-dependent plasticity without long-term depression by type 2 metabotropic glutamate receptors in developing visual cortex [O] . John J. Renger, Kenichi N. Hartman, Yoshiko Tsuchimoto, 2002

机译：2型代谢型谷氨酸受体在视觉皮层发育过程中没有长期抑制的经验依赖性可塑性
7. Experience-dependent plasticity without long-term depression by type 2 metabotropic glutamate receptors in developing visual cortex [O] . Renger, John J., Hartman, Kenichi N., Tsuchimoto, Yoshiko, 2002

机译：2型代谢型谷氨酸受体在视觉皮层发育过程中没有长期抑制的经验依赖性可塑性

Metabotropic glutamate receptor dependent long-term depression in the cortex

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