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首页> 外文期刊>The Korean Journal of Physiology & Pharmacology >Toxicokinetics of paraquat in Korean patients with acute poisoning
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Toxicokinetics of paraquat in Korean patients with acute poisoning

机译：百草枯对韩国急性中毒患者的毒代动力学

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To conduct a kinetic study of paraquat (PQ), we investigated 9 patients with acute PQ intoxication. All of them ingested more than 20 ml of undiluted PQ herbicide to commit suicide and arrived at our hospital early, not later than 7 h after PQ ingestion. The urine dithionite test for PQ in all of the nine patients was strongly positive at emergency room. Blood samples were obtained every 30 min for the first 2~3 h and then every 1 or 2 h, as long as the clinical progression was stable among the patients for 30 h after PQ ingestion. The area under the plasma concentration-time curve (AUCinf), which was extrapolated to infinity, was calculated using the trapezoidal rule. Toxicokinetic parameters, such as the terminal elimination half-life, apparent oral clearance, and apparent volume of distribution (Vd/F) were calculated. The maximum PQ concentration (Cmax) and the time to reach maximum PQ concentration (Tmax) were also obtained. Plasma PQ concentrations in nine patients were well described by a bi-exponential curve with a mean terminal elimination half-life of 13.1±6.8 h. Cmax and AUCinf were 20.8±25.7 mg/l and 172.5±160.3 h·mg/l, respectively. Apparent volume of distribution and apparent oral clearance were 50.9±61.3 l/kg and 173.4±111.2 l/h, respectively. There were a significant correlation ( r =0.84; pmax. AUCinf also showed a significant correlation ( r =0.83; p
机译：为了进行百草枯（PQ）的动力学研究，我们调查了9名急性PQ中毒患者。他们所有人都摄入了20毫升以上未稀释的PQ除草剂自杀，并提早在PQ摄入后7小时内到达我院。在急诊室，所有9例患者的PQ尿液连二亚硫酸盐检测均呈强阳性。只要在摄入PQ后的30小时内患者的临床进展稳定，则最初的2〜3小时每30分钟获取一次血液样本，然后每1或2小时获取一次。使用梯形法则计算血浆浓度-时间曲线下的面积（AUC inf ），将其外推至无穷大。计算了毒代动力学参数，例如末端消除半衰期，表观口腔清除率和表观分布体积（V d / F）。还获得了最大PQ浓度（C max ）和达到最大PQ浓度的时间（T max ）。通过双指数曲线很好地描述了九名患者的血浆PQ浓度，其平均终末消除半衰期为13.1±6.8 h。 C max 和AUC inf 分别为20.8±25.7 mg / l和172.5±160.3 h·mg / l。表观分布体积和表观口腔清除率分别为50.9±61.3 l / kg和173.4±111.2 l / h。有显着的相关性（r = 0.84; pmax 。AUC inf 也有显着的相关性（r = 0.83; p

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