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首页> 外文期刊>The Korean Journal of Physiology & Pharmacology >The advantage of topographic prominence-adopted filter for the detection of short-latency spikes of retinal ganglion cells
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The advantage of topographic prominence-adopted filter for the detection of short-latency spikes of retinal ganglion cells

机译：采用地形凸点滤镜的优势在于可检测视网膜神经节细胞的短时峰

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摘要

Electrical stimulation through retinal prosthesis elicits both short and long-latency retinal ganglion cell (RGC) spikes. Because the short-latency RGC spike is usually obscured by electrical stimulus artifact, it is very important to isolate spike from stimulus artifact. Previously, we showed that topographic prominence (TP) discriminator based algorithm is valid and useful for artifact subtraction. In this study, we compared the performance of forward backward (FB) filter only vs. TP-adopted FB filter for artifact subtraction. From the extracted retinae of rd1 mice, we recorded RGC spikes with 8×8 multielectrode array (MEA). The recorded signals were classified into four groups by distances between the stimulation and recording electrodes on MEA (200-400, 400-600, 600-800, 800-1000 μm). Fifty cathodic phase-1st biphasic current pulses (duration 500 μs, intensity 5, 10, 20, 30, 40, 50, 60 μA) were applied at every 1 sec. We compared false positive error and false negative error in FB filter and TP-adopted FB filter. By implementing TP-adopted FB filter, short-latency spike can be detected better regarding sensitivity and specificity for detecting spikes regardless of the strength of stimulus and the distance between stimulus and recording electrodes.
机译：通过视网膜假体进行电刺激会引起短期和长期潜伏的视网膜神经节细胞（RGC）尖峰。由于短时延RGC尖峰通常被电刺激伪影所掩盖，因此将尖峰与刺激伪影隔离开来非常重要。先前，我们显示了基于地形突出（TP）鉴别器的算法有效且对伪影减法有用。在这项研究中，我们比较了仅前向后（FB）滤波器与采用TP的FB滤波器进行伪影减法的性能。从rd1小鼠的提取视网膜中，我们用8×8多电极阵列（MEA）记录了RGC峰。根据MEA上刺激电极和记录电极之间的距离（200-400、400-600、600-800、800-1000μm）将记录的信号分为四类。每1秒施加50个阴极相位1ststups双相电流脉冲（持续时间500μs，强度5、10、20、30、40、50、60μA）。我们比较了FB滤波器和采用TP的FB滤波器中的误报正误率。通过实现采用TP的FB滤波器，无论刺激强度和刺激与记录电极之间的距离如何，就可以更好地检测短时延迟尖峰，这与检测尖峰的灵敏度和特异性有关。

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