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首页> 外文期刊>The Journal of toxicological sciences >Prenatal low-dose bisphenol A enhances behavioral responses induced by a predator odor
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Prenatal low-dose bisphenol A enhances behavioral responses induced by a predator odor

机译：产前低剂量双酚A可增强捕食者气味引起的行为反应

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Bisphenol A (BPA) is an environmental endocrine disrupter (EED). Previous studies by our group showed that pre- and postnatal administration of low-level BPA induced depression-like behavior in rats. In this study, we evaluated the effects of prenatal BPA on behavioral responses to a predator odor by using a novel cross-form apparatus consisting of 4 plastic chambers. On the first day, nothing was placed into the chambers (Session 1). On the second day, a predator odor (fox odor) was located in separate chambers at 2 opposite corners of the apparatus (Session 2). Pregnant Wistar rats were exposed to low-dose BPA (less than the reference dose) during the 7 days just before birth, and the offspring of the treated rats were evaluated as adults. The locomotor activity and avoidance response of each rat on both test days were compared. The control and BPA groups showed reduced locomotor activity in the presence of the predator odor, but the odor-avoidance response was significant only in the BPA rats. The BPA-exposed rats were obviously sensitive to the predator odor. These results suggest that prenatal BPA exposure has an amplifying effect on avoidance responses to predator odor stress.
机译：双酚A（BPA）是一种环境内分泌干扰物（EED）。我们小组先前的研究表明，出生前和出生后服用低水平的BPA会在大鼠中诱发抑郁样行为。在这项研究中，我们通过使用由4个塑料腔组成的新型十字形装置，评估了产前BPA对行为对捕食者气味的反应的影响。在第一天，什么都没放进房间（会议1）。在第二天，将捕食者的气味（狐臭）置于设备两个相对角的独立腔室中（会话2）。怀孕的Wistar大鼠在临产前7天就接受了低剂量的BPA（小于参考剂量），并将经治疗的大鼠的后代评估为成年。比较了两个测试日每只大鼠的运动活性和回避反应。对照组和BPA组在存在捕食者气味的情况下显示出自发运动降低，但仅在BPA大鼠中，回避气味的反应才有意义。接触双酚A的大鼠对捕食者的气味明显敏感。这些结果表明，产前BPA暴露对避免对捕食者气味压力的反应具有放大作用。

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