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首页> 外文期刊>The Journal of toxicological sciences >The effects on the endocrine system under hepatotoxicity induction by phenobarbital and di(2-ethylhexyl)phthalate in intact juvenile male rats
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The effects on the endocrine system under hepatotoxicity induction by phenobarbital and di(2-ethylhexyl)phthalate in intact juvenile male rats

机译：苯巴比妥和邻苯二甲酸二（2-乙基己基）酯对未成年雄性大鼠肝毒性诱导的内分泌系统的影响

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Phenobarbital (PB) and Di (2-ethylhexyl) phthalate (DEHP), an anti-epileptic drug and a plasticizer used in flexible polyvinylchloride formulations, respectively, are well-known typical hepatotoxicants. This study investigated the effects of PB (100 mg/kg/day) or DEHP (500 mg/kg/day) on the endocrine system in intact juvenile/peripubertal male rats exposed for 31 days beginning on postnatal day 23. Slight hormone level changes, histopathological changes in thyroid gland or induction of UDP-glucuronosyltransferase in liver were observed in both the PB and DEHP groups. One of the assumed mechanisms inducing thyroid effects is predictable to be secondary changes based on the enhancement in thyroid hormone metabolism via the induction of hepatic microsomal enzymes. No reproductive system-related changes in organ weights, histopathology, and sexual maturation were observed in both groups. Lower testosterone level was observed in the PB group. CYP2B and CYP3A, which are involved in testosterone metabolism, were induced in liver of the PB group. There was no change of 17β-hydroxysteroid dehydrogenase activity in testis of both groups. Lower testosterone level in the PB-treated male rats was attributed to an indirect, hepatotoxicity-associated effect on the reproductive system and not to direct effects on testis such as the antiandrogenic activity and the inhibition of steroidogenesis. These results did not indicate that PB or DEHP exposure affects the endocrine system directly.
机译：苯巴比妥（PB）和邻苯二甲酸二（2-乙基己基）酯（DEHP），分别是用于柔性聚氯乙烯制剂的抗癫痫药和增塑剂，是众所周知的典型肝毒性剂。这项研究调查了从出生后第23天开始暴露31天的完整幼稚/青春期雄性大鼠中PB（100 mg / kg / day）或DEHP（500 mg / kg / day）对内分泌系统的影响。 PB和DEHP组均观察到甲状腺的组织病理学变化或肝脏中UDP-葡萄糖醛酸转移酶的诱导。诱导甲状腺作用的假设机制之一是可预测的是继发性变化，其基础是通过肝微粒体酶的诱导，甲状腺激素代谢增强。两组均未观察到与生殖系统有关的器官重量，组织病理学和性成熟变化。 PB组的睾丸激素水平较低。 CYP2B和CYP3A参与了睾丸激素的代谢，在PB组的肝脏中被诱导。两组睾丸中17β-羟类固醇脱氢酶活性均无变化。 PB处理的雄性大鼠睾丸激素水平降低归因于对生殖系统的间接，肝毒性相关作用，而不是对睾丸的直接作用，例如抗雄激素活性和类固醇生成抑制作用。这些结果并未表明PB或DEHP暴露直接影响内分泌系统。

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