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首页> 外文期刊>The Journal of toxicological sciences >Long-term dietary intake of excessive vitamin A impairs spermatogenesis in mice
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Long-term dietary intake of excessive vitamin A impairs spermatogenesis in mice

机译：长期饮食中过量摄入维生素A会损害小鼠的精子发生

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Vitamin A and its derivatives contribute to many physiological processes, including vision, neural differentiation, and reproduction. Vitamin A deficiency causes early cessation of spermatogenesis, characterized by a marked depletion of germ cells. However, there has been no clear understanding about the role of chronic intake of vitamin A excess (VAE) in spermatogenesis. The objective of this study was to investigate whether chronic intake of VAE diet causes arrest of spermatogenesis. To examine the effects of VAE on spermatogenesis, we used ICR male mice fed with control (AIN-93G purified diet: 4 IU/g) diet or VAE (modified AIN-93G diet with VAE: 1,000 IU/g) diet for 7 weeks (from 3 to 10 weeks of age). At 10 weeks of age, the retinol concentration in the testes of VAE mice was significantly higher than that of control mice. Testicular cross sections from control mice contained a normal array of germ cells, while the seminiferous tubules from VAE mice exhibited varying degrees of testicular degeneration. Daily sperm production in VAE testes was dramatically decreased compared to that in control testes. Sperm viability, motility, and morphology were also impaired in VAE mice. Furthermore, we examined the effects of VAE on the expression of genes involved in retinoid signaling and spermatogenesis to determine the underlying molecular mechanisms. Therefore, we are the first to present results describing the long-term dietary intake of VAE impairs spermatogenesis using a mouse model.
机译：维生素A及其衍生物有助于许多生理过程，包括视觉，神经分化和繁殖。维生素A缺乏会导致精子生成提前停止，其特征是生殖细胞明显枯竭。但是，关于长期摄入过量维生素A（VAE）在精子发生中的作用还没有明确的认识。这项研究的目的是调查长期摄入VAE饮食是否会导致精子发生停止。为了检查VAE对精子发生的影响，我们用ICR雄性小鼠饲喂对照（AIN-93G纯饮食：4 IU / g）饮食或VAE（改良的AIN-93G VAE：1,000 IU / g）饮食7周（3至10周龄）。在10周龄时，VAE小鼠睾丸中的视黄醇浓度显着高于对照小鼠。来自对照小鼠的睾丸横截面包含正常的生殖细胞阵列，而来自VAE小鼠的生精小管表现出不同程度的睾丸变性。与对照睾丸相比，VAE睾丸的每日精子产量显着下降。在VAE小鼠中，精子的活力，运动性和形态也受到损害。此外，我们检查了VAE对类视色素信号传导和精子发生相关基因表达的影响，以确定潜在的分子机制。因此，我们是第一个提出使用小鼠模型描述VAE长期饮食摄入会损害精子发生的结果。

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