S-1 is an anticancer agent that consists of tegafur, gimeracil, and oteracil potassium at a molar ratio of 1:0.4:1. S-1 is used to treat metastatic and resectable gastric cancer. However, the extensive use of S-1 in clinical practice results in watery eyes, a serious clinical problem, which worsens patients’ quality of life. Although repeated instillation of artificial tears is recommended, therapy or prophylaxis against S-1-induced ocular toxicity has not been established. In the present study, we evaluated the alleviating effects of repeated artificial tear instillation on S-1-induced ocular toxicity in dogs. Ten beagle dogs (5 males and 5 females) were orally administered 3 mg/kg/day of S-1 for up to 21 days. Five drops of artificial tears were instilled to the left eye, eight times daily, within 6 hr after S-1 administration. The mean cornea staining score tended to be low in the left eye with repeated artificial tear instillation. In 4 out of 10 dogs, the corneal staining score of the left eye was more than 2-fold lower than that of the right eye. The incidence of dogs indicating normal tear drainage increased and stenosed tear drainage decreased by repeated artificial tear instillation. In conclusion, we demonstrated that artificial tear instillation can alleviate corneal surface damage induced by S-1 in dogs.
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机译：S-1是一种抗癌药，它由替加福，吉美拉西和奥托拉西钾组成，摩尔比为1：0.4：1。 S-1用于治疗转移性和可切除的胃癌。但是，在临床实践中广泛使用S-1会导致流眼水，这是一个严重的临床问题，使患者的生活质量恶化。尽管建议反复滴注人造眼泪，但尚未建立针对S-1诱导的眼毒性的治疗或预防措施。在本研究中，我们评估了重复人工泪液滴注对S-1诱导的犬眼毒性的缓解作用。十只比格犬（5只雄性和5只雌性）每天口服3 mg / kg /天的S-1，最多服用21天。 S-1给药后6小时内，每天八次向左眼滴入五滴人工泪液。重复进行人工泪液滴注后，左眼的平均角膜染色评分往往较低。 10只狗中有4只的左眼角膜染色得分比右眼低2倍以上。反复进行人工泪液滴注表明正常的泪液引流的狗的发生率增加，而狭窄的泪液引流的狗的发生率降低。总之，我们证明了人工泪液滴注可以减轻狗中S-1诱导的角膜表面损伤。
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