...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The Journal of toxicological sciences >No toxicological effects on acute and repeated oral gavage doses of single-wall or multi-wall carbon nanotube in rats
【24h】

No toxicological effects on acute and repeated oral gavage doses of single-wall or multi-wall carbon nanotube in rats

机译：对大鼠单壁或多壁碳纳米管急性和反复口服管饲剂量无毒理学影响

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Three female Crl:CD(SD) rats/group were dosed with single wall carbon nanotube (SWCNT) or multi wall carbon nanotube (MWCNT) four times by gavage at a total of 50 mg/kg bw or 200 mg/kg bw (four equally divided doses at one-hour intervals). Acute oral doses of SWCNT and MWCNT caused neither death nor toxicological effects, and thus the oral LD50 values for SWCNT and MWCNT were considered to be greater than 50 mg/kg bw and 200 mg/kg bw, in rats respectively. Five or ten Crl:CD(SD) rats/sex were dosed with SWCNT once daily by gavage at a dose of 0 (control), 0.125, 1.25 or 12.5 mg/kg bw/day for 28 days with a 14-day recovery period (0 and 12.5 mg/kg bw/day groups). Six or twelve Crl:CD(SD) rats/sex were dosed with MWCNT once daily by gavage at a dose of 0 (control), 0.5, 5.0 or 50 mg/kg bw/day for 28 days with a 14-day recovery period (0 and 50 mg/kg bw/day groups). Based on no toxicological effects, the no observed adverse effect levels (NOAELs) of repeated dose toxicity of SWCNT and MWCNT were considered to be 12.5 mg/kg bw/day and 50 mg/kg bw/day (the highest dose tested), respectively. It was suggested that SWCNT and MWCNT dosed by gavage reached the gastro-intestinal tract as agglomerates and were mostly excreted via feces.
机译：每只三只雌性Crl：CD（SD）大鼠/组分别通过管饲法以单壁碳纳米管（SWCNT）或多壁碳纳米管（MWCNT）给药四次，总剂量为50 mg / kg bw或200 mg / kg bw（四次以一小时为间隔平均分配剂量）。急性口服SWCNT和MWCNT既没有引起死亡也没有毒理作用，因此SWCNT和MWCNT的口服LD 50 值被认为大于50 mg / kg bw和200 mg / kg bw，在大鼠中。每天通过管饲法向五只或十只Crl：CD（SD）大鼠/性别施以SWCNT一次，剂量为0（对照组），0.125、1.25或12.5 mg / kg bw /天，持续28天，恢复期为14天（0和12.5 mg / kg bw /天组）。每天六只或十二只Crl：CD（SD）大鼠/性别通过管饲法每天一次给予MWCNT，剂量为0（对照组），0.5、5.0或50 mg / kg bw /天，持续28天，恢复期为14天（0和50 mg / kg bw /天组）。基于无毒理学作用，SWCNT和MWCNT的重复剂量毒性的未观察到的不良影响水平（NOAEL）分别被认为是12.5 mg / kg bw /天和50 mg / kg bw /天（测试的最高剂量） 。有人建议，管饲法给予的SWCNT和MWCNT以团聚的形式到达胃肠道，并且大部分通过粪便排泄。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号