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首页> 外文期刊>The Journal of toxicological sciences >Testicular spermiation failure in rats exposed prenatally to 3,3′,4,4′,5-pentachlorobiphenyl
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Testicular spermiation failure in rats exposed prenatally to 3,3′,4,4′,5-pentachlorobiphenyl

机译：产前暴露于3,3'，4,4'，5-五氯联苯的大鼠睾丸精子衰竭

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摘要

Testicular spermatogenesis was studied in 7-, 10-, 13- and 17-week-old Sprague-Dawley rats whose dams had been administered intragastrically with 2.5, 25, or 250 ng of 3,3′,4,4′,5-pentachlorobiphenyl (PCB126) or vehicle on days 13-19 of gestation. The 250 ng groups among the 7-, 10- and 13-week-old offspring showed significant inhibition of mature spermatid release (spermiation), but 17-week-old offspring did not show this. These alterations were not observed in other PCB126 and vehicle groups, and no germ cell or Sertoli cell degeneration were observed in any group. Spermiation failure at puberty appeared in those rats born to dams exposed 250 ng/kg PCB126 on days 13-19 of gestation was reversible change that recovered at adulthood. Because the serum testosterone, luteinizing hormone and follicle-stimulating hormone concentrations were similar in the PCB126 and vehicle groups, a direct endocrine cause for the observed effects was unlikely.
机译：在7周，10周，13周和17周的Sprague-Dawley大鼠中研究了睾丸的精子发生过程，这些大鼠的胃内注射了2.5、25或250 ng的3,3'，4,4'，5-。妊娠第13-19天的五氯联苯（PCB126）或媒介物。在7、10和13周龄的后代中，250 ng组对成熟精子的释放（杀精）有明显的抑制作用，而17周龄的后代则没有。在其他PCB126和媒介物组中未观察到这些改变，在任何组中均未观察到生殖细胞或支持细胞的变性。那些在妊娠第13-19天暴露于250 ng / kg PCB126的水坝出生的大鼠出现青春期精子衰竭，这是可逆的变化，成年后恢复。由于PCB126组和赋形剂组的血清睾丸激素，促黄体生成激素和促卵泡激素浓度相似，因此不太可能直接由内分泌原因引起观察到的影响。

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