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首页> 外文期刊>The Journal of toxicological sciences >Long-term administration of excess zinc impairs learning and memory in aged mice
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Long-term administration of excess zinc impairs learning and memory in aged mice

机译：长期服用过量锌会损害老年小鼠的学习和记忆能力

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Zinc (Zn) is an essential element, but excess amounts are known to cause neurotoxic effects. The risk of excessive Zn intake is increased by supplementing food intake with dietary supplements. Ageing affects many cellular processes that predispose individuals to neurodegeneration. Indeed, the prevalence of senile dementia such as Alzheimer’s disease, Parkinson’s disease, and vascular-type dementia increases with age. As such, we investigated the effects of long-term exposure to excess Zn on learning and memory in aged mice. ICR-JCL female mice (aged 26 weeks) were administered 0, 200, or 500 ppm Zn as zinc chloride in drinking water for 30 weeks. After 30-week administration, aged female animals were subjected to Y-maze, novel object recognition, and step-through passive avoidance tests. Chronic exposure to Zn did not inhibit learning and memory in the Y-maze test, but dose-dependently inhibited learning and memory in novel object recognition and step-through passive avoidance tests. These results indicate the potential for chronic Zn exposure to dose-dependently inhibit both long-term and novel object recognition memory. Results of microarray analysis revealed significant changes in gene expression of transthyretin and many olfactory receptors in the hippocampus of Zn-treated mice.
机译：锌（Zn）是必不可少的元素，但已知过量会引起神经毒性。通过饮食补充膳食补充剂来增加锌摄入过多的风险。衰老影响许多使个体容易发生神经退行性变的细胞过程。实际上，老年痴呆症（如阿尔茨海默氏病，帕金森氏病和血管性痴呆）的患病率随年龄增长而增加。因此，我们调查了长期暴露于过量锌对衰老小鼠学习和记忆的影响。对ICR-JCL雌性小鼠（26周龄）在饮用水中施用0、200或500 ppm的氯化锌锌，持续30周。给药30周后，对成年雌性动物进行Y迷宫，新颖物体识别和逐步被动回避测试。长期暴露于Zn不会在Y迷宫测试中抑制学习和记忆，但是在新型物体识别和逐步被动回避测试中，剂量依赖性地抑制了学习和记忆。这些结果表明，慢性锌暴露剂量依赖性抑制长期和新型物体识别记忆的潜力。基因芯片分析的结果显示，锌处理的小鼠海马中的运甲状腺素蛋白和许多嗅觉受体的基因表达发生了显着变化。

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