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首页> 外文期刊>The Journal of toxicological sciences >Testosterone-lowering activity of canola and hydrogenated soybean oil in the stroke-prone spontaneously hypertensive rat
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Testosterone-lowering activity of canola and hydrogenated soybean oil in the stroke-prone spontaneously hypertensive rat

机译：中风易发性高血压大鼠低芥酸菜籽和氢化大豆油降低睾丸激素的活性

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摘要

Canola and some other types of oil unusually shorten the survival of stroke-prone spontaneously hypertensive rats (SHRSP), compared with soybean oil, perilla oil and animal fats. Since differential effects of canola and soybean oil on steroid hormone metabolism were suggested by a preliminary DNA microarray analysis as a reason for this, the steroid hormone levels in the serum and tissues of SHRSP fed different oils were investigated. The testosterone levels in the serum and the testes were found to be significantly lower in the canola oil group than in the soybean oil group, while no significant differences were detected in the corticosterone and estradiol levels in tissues. In a second experiment, it was found that hydrogenated soybean oil, with a survival-shortening activity comparable to that of canola oil, also decreased the testosterone level in testes to a similar degree. The testosterone-lowering activity of canola and hydrogenated soybean oil observed in SHRSP was considered in relation to other factors possibly affecting the physiology of SHRSP.
机译：与大豆油，紫苏油和动物脂肪相比，低芥酸菜子油和某些其他类型的油通常会缩短中风易发性自发性高血压大鼠（SHRSP）的存活时间。由于初步的DNA芯片分析表明低芥酸菜子油和大豆油对类固醇激素代谢有不同的作用，这是其原因，因此，我们研究了SHRSP饲喂不同油类的血清和组织中类固醇激素水平。在低芥酸菜子油组中，发现血清和睾丸中的睾丸激素水平显着低于大豆油组，而在组织中，皮质酮和雌二醇水平未发现显着差异。在第二个实验中，发现氢化大豆油具有与低芥酸菜子油相当的存活缩短活性，也使睾丸中的睾丸激素水平降低了相似的程度。 SHRSP中观察到的低芥酸菜籽和氢化大豆油降低睾丸激素的活性被认为与可能影响SHRSP生理的其他因素有关。

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