...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The Journal of toxicological sciences >Genotoxicity detection of five medicinal plants in Nigeria
【24h】

Genotoxicity detection of five medicinal plants in Nigeria

机译：尼日利亚五种药用植物的遗传毒性检测

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

This study was performed to investigate the safety of Alchornea cordifolia , Cnestis ferruginea , Lonchocarpus sericeus , Trema orientalis, and Senna alata in respect to genotoxicity. These five medicinal plants are widely distributed in Africa. They are used as a traditional medicine in many African counties for the treatment of microbial, inflammatory, and stress-related diseases. To evaluate the bacterial reverse mutation of these five medicinal plants, the in vitro Ames test using Salmonella typhimurium TA98, TA100, TA1535, and TA1537, and Escherichia coli WP2 uvr A, with or without the addition of S9 mixture was performed. Concentrations used for this test were 625, 2,500, and 5,000 μg per plate. A. cordifolia , C. ferruginea , L. sericeus , and T. orientalis showed negative results in the bacterial reverse mutation test, suggesting that it is potentially safe for these plants to be used in medicinal plants supplements at high doses. However, our experiments suggest that S. alata is a potent mutagen. Therefore, further studies are needed to evaluate the carcinogenicity of S. alata in order to adequately assess the risks for human health.
机译：进行这项研究的目的是就基因毒性研究调查Alchornea cordifolia，Cnestis ferruginea，Lonchocarpus sericeus，Trema Orientalis和Senna alata的安全性。这五种药用植物在非洲广泛分布。它们在许多非洲县用作治疗微生物，炎性疾病和与压力有关的疾病的传统药物。为了评估这五种药用植物的细菌反向突变，使用鼠伤寒沙门氏菌TA98，TA100，TA1535和TA1537以及大肠杆菌WP2 uvr A进行了体外Ames测试，添加或不添加S9混合物。用于该测试的浓度为每板625、2,500和5,000μg。在细菌反向突变测试中，堇菜叶念珠菌，C。ferruginea，L。sericeus和东方侧柏显示阴性结果，表明这些植物以高剂量用于药用植物补品中是潜在安全的。但是，我们的实验表明，S。alata是一种有效的诱变剂。因此，需要进行进一步的研究来评估S. alata的致癌性，以充分评估对人类健康的风险。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号