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首页> 外文期刊>The Journal of toxicological sciences >Spontaneous reactivation and aging kinetics of acetylcholinesterase inhibited by dichlorvos and diazinon
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Spontaneous reactivation and aging kinetics of acetylcholinesterase inhibited by dichlorvos and diazinon

机译：敌敌畏和二嗪农抑制乙酰胆碱酯酶的自发活化和衰老动力学

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摘要

Organophosphorus (OP) are among the most toxic of all substances that cause poisoning in food animals and are the most frequently encountered insecticides, commonly detected in agricultural products, animal-derived foodstuffs, environmental samples, and home use and represent a significant potential health risk. The first-order rate constants obtained for spontaneous reactivation ( k s) was found to be higher in sheep compared to cattle, pig, and ranged between 0.133 to 0.323 hr-1 and between 0.021 to 0.088 hr-1 for dichlorvos (DDVP) and diazinon (DZN) respectively. Aging of phosphorylated acetylcholinesterase (AChE) follows the kinetics of a first-order reaction with rate constants of aging ( k a) higher in cattle compared to sheep and pig, and ranged between 0.013 to 0.021 hr-1 and between 0.009 to 0.01 hr-1 for DDVP and DZN respectively. Half-time (t1/2) for spontaneous reactivation and aging are higher in DZN compared to DDVP and ranged from 2.3 to 85.3 hr (sheep), 3.2 to 76.3 hr (cattle), and 2.9 to 58.3 hr (pig), respectively.
机译：有机磷（OP）是所有可导致食用动物中毒的物质中毒性最高的物质，并且是最常见的杀虫剂，通常在农产品，动物源性食品，环境样品和家庭使用中检出，并具有重大的潜在健康风险。发现自发激活获得的一级速率常数（k s ）在绵羊中比在牛，猪中更高，范围在0.133至0.323 hr -1 敌敌畏（DDVP）和二嗪农（DZN）分别在0.021至0.088 hr -1 之间。磷酸化乙酰胆碱酯酶（AChE）的老化遵循一阶反应的动力学，与绵羊和猪相比，牛的老化速率常数（k a ）高，介于0.013至0.021 hr -1 和0.009到0.01 hr -1 。与DDVP相比，DZN中自发激活和老化的半衰期（t 1/2 ）更高，范围为2.3至85.3 hr（羊），3.2至76.3 hr（牛）和2.9至58.3小时（猪）。

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