...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The Korean Journal of Physiology & Pharmacology >Changes of Atrial Natriuretic Peptide System in Rats with Puromycin Aminonucleoside-Induced Nephrotic Syndrome
【24h】

Changes of Atrial Natriuretic Peptide System in Rats with Puromycin Aminonucleoside-Induced Nephrotic Syndrome

机译：嘌呤霉素氨基核苷酸致肾病综合征大鼠心钠素系统的变化

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Sodium retention is a hallmark of nephrotic syndrome. We investigated whether sodium retention is associated with changes of natriuretic peptide system at different stages (i.e., a sodium retaining stage and a compensatory stage) of nephrotic syndrome. At day 7 after PAN (puromycin aminonucleoside) injection, the urinary excretion of sodium was decreased, along with the development of ascites and positive sodium balance. The plasma and urinary ANP (atrial natriuretic peptide) immunoreactivities were increased. ANP mRNA expression was increased in the heart and kidney, whereas that of NPR (natriuretic peptide receptor)-A and NPR-C mRNA was decreased in the kidney. The expression of NEP was decreased in the kidney. At day 14, urinary excretion of sodium did not differ from the control. The plasma ANP level and heart ANP mRNA expression returned to their control values. The expression of ANP mRNA in the kidney was increased in association with increased urinary ANP immunoreactivities. The expression of NPR-A in the kidney became normal, whereas that of NPR-C kept decreased. The expression of NEP (neutral endopeptidase) remained decreased. These findings suggest that the increased renal ANP synthesis in association with decreased metabolism via NEP and NPR-C may play a compensatory role against the development of sodium retention in nephrotic syndrome. The decreased of NPR-A expression in the kidney may contribute to the ANP resistance at day 7. The subsequent recovery of NPR-A expression may play a role in promoting sodium excretion in later stage (at day 14).
机译：钠retention留是肾病综合征的标志。我们研究了在肾病综合征的不同阶段（即钠保留期和代偿期）钠保留是否与利钠肽系统的变化有关。注射PAN（嘌呤霉素氨基核苷）后第7天，尿液的钠排泄减少，伴随腹水的形成和钠平衡的增加。血浆和尿ANP（心钠素）的免疫反应性增加。在心脏和肾脏中，ANP mRNA表达增加，而在肾脏中，NPR（利钠肽受体）-A和NPR-C mRNA的表达降低。肾脏中NEP的表达降低。在第14天，钠的尿排泄与对照无差异。血浆ANP水平和心脏ANP mRNA表达恢复至对照值。肾脏中ANP mRNA的表达与尿ANP免疫反应性的增加有关。肾脏中NPR-A的表达恢复正常，而NPR-C的表达持续下降。 NEP（中性内肽酶）的表达仍然降低。这些发现表明，肾脏NNP合成的增加与通过NEP和NPR-C的代谢减少有关，可能对肾病综合征中钠retention留的发展起补偿作用。肾脏中NPR-A表达的降低可能在第7天有助于ANP抵抗。随后NPR-A表达的恢复可能在后期（第14天）促进钠排泄。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号