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首页> 外文期刊>The Korean Journal of Physiology & Pharmacology >Effects of Isoflurane Anesthesia on Post-Anesthetic Sleep-Wake Architectures in Rats
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Effects of Isoflurane Anesthesia on Post-Anesthetic Sleep-Wake Architectures in Rats

机译：异氟烷麻醉对大鼠麻醉后觉醒结构的影响

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The sleep homeostatic response significantly affects the state of anesthesia. In addition, sleep recovery may occur during anesthesia, either via a natural sleep-like process to occur or via a direct restorative effect. Little is known about the effects of isoflurane anesthesia on sleep homeostasis. We investigated whether 1) isoflurane anesthesia could provide a sleep-like process, and 2) the depth of anesthesia could differently affect the post-anesthesia sleep response. Nine rats were treated for 2 hours with ad libitum sleep (Control), sleep deprivation (SD), and isoflurane anesthesia with delta-wave-predominant state (ISO-1) or burst suppression pattern-predominant state (ISO-2) with at least a 1-week interval. Electroencephalogram and electromyogram were recorded and sleep-wake architecture was evaluated for 4 hours after each treatment. In the post-treatment period, the duration of transition to slow-wave-sleep decreased but slow wave sleep (SWS) increased in the SD group, but no sleep stages were significantly changed in ISO-1 and ISO-2 groups compared to Control. Different levels of anesthesia did not significantly affect the post-anesthesia sleep responses, but the deep level of anesthesia significantly delayed the latency to sleep compared to Control. The present results indicate that a natural sleep-like process likely occurs during isoflurane anesthesia and that the post-anesthesia sleep response occurs irrespective to the level of anesthesia.
机译：睡眠稳态反应显着影响麻醉状态。另外，在麻醉期间，睡眠恢复可以通过自然的类睡眠过程发生或通过直接恢复作用发生。关于异氟烷麻醉对睡眠稳态的影响知之甚少。我们调查了1）异氟醚麻醉是否可以提供类似睡眠的过程，以及2）麻醉深度可能不同地影响麻醉后的睡眠反应。对9只大鼠进行了2个小时的随意睡眠（对照），睡眠剥夺（SD）和异氟烷麻醉，以δ波为主的状态（ISO-1）或以突发抑制模式为主的状态（ISO-2）进行了2小时的治疗，至少间隔1周。记录脑电图和肌电图，并在每次治疗后4小时评估睡眠-觉醒结构。在治疗后期间，SD组向慢波睡眠的过渡时间减少，但慢波睡眠（SWS）增加，但与对照组相比，ISO-1和ISO-2组的睡眠阶段没有明显改变。不同水平的麻醉并没有显着影响麻醉后的睡眠反应，但与对照相比，深麻醉水平显着延迟了睡眠潜伏期。目前的结果表明，异氟醚麻醉期间可能会发生类似自然的睡眠过程，并且麻醉后的睡眠反应会与麻醉剂的水平无关。

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