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首页> 外文期刊>The Open Anesthesia Journal >A Comparative Study of Three Nebulized Medications for the Prevention of Postoperative Sore Throat in the Pediatric Population
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A Comparative Study of Three Nebulized Medications for the Prevention of Postoperative Sore Throat in the Pediatric Population

机译：三种雾化药物预防小儿术后喉咙痛的比较研究

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Background: The delivery of aerosolized drugs is a vital component of treatment for many respiratory disorders. We used this mode of medication delivery as a pre-emptive strategy to alleviate a Postoperative Sore Throat (POST) in children receiving general anesthesia. Objectives: The primary aim of the study was to compare the effects of prophylactic ketamine, magnesium sulfate and dexamethasone nebulization, on the intensity of POST. Methods: Through a prospective, randomized, double-blind study, data were collected from children (6-16 years) undergoing surgeries from March 2018 to May 2018. The patients were allocated into 3 equivalent groups (36 patients each). Preoperative nebulization was performed for all patients. Group M received 40 mg/kg magnesium sulphate, group K received 1 mg/kg ketamine, and group D received 0.16 mg dexamethasone. The primary outcome of the study was the incidence and intensity of POST at the 4th postoperative hour. The secondary outcomes included evaluation of adverse effects specifically nausea, vomiting, postoperative cough and postoperative sedation. Results: Patients in the K group had the lowest incidence of POST compared to patients in groups M and D, specifically, at the 4th - postoperative hour (p-value = 0.003). Conclusions: Preoperative nebulization with ketamine was more effective in reducing the intensity of POST in pediatric patients postoperatively without systemic adverse effects.
机译：背景：雾化药物的输送是许多呼吸系统疾病治疗的重要组成部分。我们使用这种药物输送模式作为先发制人的策略，以减轻接受全身麻醉的儿童的术后咽喉痛（POST）。目的：本研究的主要目的是比较预防性氯胺酮，硫酸镁和地塞米松雾化对POST强度的影响。方法：通过一项前瞻性，随机，双盲研究，收集了2018年3月至2018年5月接受手术的儿童（6至16岁）的数据。将患者分为3个等效组（每组36个患者）。对所有患者进行术前雾化。 M组接受40 mg / kg硫酸镁，K组接受1 mg / kg氯胺酮，D组接受0.16 mg地塞米松。该研究的主要结果是术后第4小时POST的发生率和强度。次要结果包括评估不良反应，特别是恶心，呕吐，术后咳嗽和术后镇静。结果：与M和D组相比，K组患者的POST发生率最低，特别是在术后第4小时（p值= 0.003）。结论：氯胺酮术前雾化可以更有效地降低小儿术后的POST强度，而无全身不良反应。

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