Repeated Intranasal Flumazenil Administration in Adult Subjects During Prolonged Benzodiazepine-induced Sedation

Trevor J. Szymanski; Michael D. Curley; Mirjana M. Lovrincevic; Beverly K. Philip; Juli Wyle-gala; Massimo Ferrigno

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Repeated Intranasal Flumazenil Administration in Adult Subjects During Prolonged Benzodiazepine-induced Sedation

机译：苯并二氮杂induced长期镇静期间成年受试者反复鼻内注射氟马西尼

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As part of a study exploring the use of oral diazepam to reduce carbon dioxide production and extend survival in a disabled submarine, intranasal flumazenil was used repeatedly over 48 hours to intermittently reverse benzodiazepine-induced sedation in six adult male subjects. Previous reports of intranasal flumazenil have been limited to pediatric pa-tients. Here we report the time course of administration of intranasal flumazenil and its effects on adult subjects, in whom flumazenil was given during sedation/reversal/re-sedation cycles. Sedation scores increased with flumazenil administra-tion in 24 of the 30 cycles, and in 100% of cases when subjects were at deeper levels of sedation.

机译：作为探索使用口服地西epa减少二氧化碳含量并延长潜艇寿命的一项研究的一部分，鼻内氟马西尼在48小时内反复使用，以间歇性地逆转六名成年男性受试者中苯二氮卓诱导的镇静作用。以前鼻内氟马西尼的报道仅限于儿科患者。在这里，我们报告了鼻内给予氟马西尼的时间过程及其对成年受试者的影响，在镇静/逆转/再镇静周期中给予了氟马西尼。在30个疗程中有24个疗程使用氟马西尼镇静分数增加，在受试者处于较深镇静水平时100％的情况下。

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《The Open Anesthesiology Journal》 |2017年第1期|共4页
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Trevor J. Szymanski; Michael D. Curley; Mirjana M. Lovrincevic; Beverly K. Philip; Juli Wyle-gala; Massimo Ferrigno;
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1. Repeated Intranasal Flumazenil Administration in Adult Subjects During Prolonged Benzodiazepine-induced Sedation [J] . Szymanski Trevor J., Curley Michael D., Lovrincevic Mirjana M., The Open Anesthesia Journal . 2013,第1期

机译：苯并二氮杂induced长期镇静期间成年受试者反复鼻内注射氟马西尼
2. A comparison of 3 routes of flumazenil administration to reverse benzodiazepine-induced desaturation in an animal model. [J] . Unkel JH, Brickhouse TH, Sweatman TW, Pediatric dentistry . 2006,第4期

机译：在动物模型中比较氟马西尼3种途径逆转苯并二氮杂pine诱发的去饱和的途径。
3. Administration of additional analgesics can decrease the incidence of paradoxical reactions in patients under benzodiazepine-induced sedation during endoscopic transpapillary procedures: Prospective randomized controlled trial [J] . TeruiT., InomataM. Digestive endoscopy: official journal of the Japan Gastroenterological Endoscopy Society . 2013,第1期

机译：在内窥镜经乳头内窥镜检查过程中，在镇静状态下给予其他镇痛药可降低患者在苯二氮卓类镇静作用下出现悖论性反应的可能性：前瞻性随机对照试验
4. Intranasal dosage forms of nicotine for prolonged delivery [C] . Byung Hwa Jung, Chang-Koo Shim International symposium on controlled release of bioactive materials;Consumer and diversified products conference . 2000

机译：尼古丁鼻内剂型可延长给药时间
5. A comparison of sublingual and intranasal routes for administration of vitamin B12 to human subjects. [D] . Ramirez, Maurice Anthony. 2009

机译：维生素B12向人类受试者给药的舌下和鼻内途径的比较。
6. Safety and Pharmacokinetics of GSK364735 a Human Immunodeficiency Virus Type 1 Integrase Inhibitor following Single and Repeated Administration in Healthy Adult Subjects [O] . Y. Sunila Reddy, Sherene S. Min, Julie Borland, 2007

机译：在健康成人受试者中单次或重复给药后人类免疫缺陷病毒1型整合酶抑制剂GSK364735的安全性和药代动力学
7. Safety and Pharmacokinetics of GSK364735, a Human Immunodeficiency Virus Type 1 Integrase Inhibitor, following Single and Repeated Administration in Healthy Adult Subjects▿ [O] . Reddy, Y. Sunila, Min, Sherene S., Borland, Julie, 2007

机译：在健康成年人中单次和重复给药后，人类免疫缺陷病毒1型整合酶抑制剂GSK364735的安全性和药代动力学▿

Repeated Intranasal Flumazenil Administration in Adult Subjects During Prolonged Benzodiazepine-induced Sedation

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