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首页> 外文期刊>The Open Anesthesiology Journal >Impact of Sub-Anesthetic Dose of Ketamine on Post Spinal Hypotension in Cesarean Delivery
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Impact of Sub-Anesthetic Dose of Ketamine on Post Spinal Hypotension in Cesarean Delivery

机译：亚麻醉剂量氯胺酮对剖宫产患者脊柱后低血压的影响

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Background: Spinal anesthesia is the commonest technique used in Cesarean Section (CS) and most frequently associated with maternal hypotension, for which a lot of techniques have been described to prevent but an effective method is yet to be found. Objectives; The aim was to study the effect of using a sub-anesthetic dose of ketamine to prevent post-spinal hypotension in CS delivery. Methods: This double-blinded randomized controlled study was conducted on 80 participating parturients who were ASA ?, П term pregnant. All the parturients received spinal anesthesia. The parturients were then randomly divided into two equal groups (n= 40 in each); ketamine group received a sub-anesthetic dose of ketamine of 0.5 mg/kg IV bolus in 3 ml saline and control group received the same volume of normal saline IV bolus. Heart Rate (HR) and Mean Arterial blood Pressure (MAP) were recorded at baseline (5 minutes prior to the intrathecal injection), at 5, 10, 15 and 20 minutes after the injection and then every 15 minutes till the end of the operation. Incidences of hypotension and severe hypotension were recorded. The total dose of ephedrine was recorded. Ramsay sedation score was recorded at baseline then 5, 10, 15, 30, 45 minutes after injection and then at the end of the operation. Results: Compared to the control group, sedation score was significantly higher among ketamine group at 5, 10 and 15 minutes. MAP and HR were significantly higher among ketamine group at 5, 10, 15, and 20 minutes. Total ephedrine dose was significantly lower among the ketamine group. Mild hypotension and severe hypotension were significantly less frequent among the ketamine group, as all the patients in the control group had an attack of mild hypotension and 55% of this group had an attack of severe hypotension. No significant difference between both the groups regarding diplopia, nystagmus, hallucination, nausea and vomiting. Conclusion: It is concluded that ketamine in a sub-anesthetic dose is an effective agent that can be used in preventing post-spinal hypotension in parturients undergoing CS delivery.
机译：背景：脊髓麻醉是剖宫产（CS）中使用的最普遍的技术，并且最常与产妇低血压有关，为此已经描述了许多预防方法，但尚未找到有效的方法。目标;目的是研究使用亚麻醉剂量的氯胺酮预防CS递送中脊柱后低血压的效果。方法：这项双盲随机对照研究是针对80名ASA？，П足月妊娠的参与产妇进行的。所有产妇均接受了脊髓麻醉。然后将产妇随机分为两个相等的组（每组n = 40）;氯胺酮组在3毫升生理盐水中接受亚麻醉剂量的氯胺酮0.5毫克/千克静脉推注，对照组接受相同体积的生理盐水静脉推注。在基线时（鞘内注射前5分钟），注射后5、10、15和20分钟记录心率（HR）和平均动脉血压（MAP），然后每15分钟记录一次，直到手术结束。记录低血压和严重低血压的发生率。记录麻黄碱的总剂量。在注射后5、10、15、30、45分钟的基线记录Ramsay的镇静分数，然后在手术结束时记录。结果：与对照组相比，氯胺酮组在5、10和15分钟时的镇静评分明显更高。在5、10、15和20分钟时，氯胺酮组的MAP和HR显着较高。氯胺酮组中的麻黄碱总剂量显着降低。氯胺酮组中轻度低血压和严重低血压的发生率显着降低，因为对照组中的所有患者都患有轻度低血压，而该组中有55％的患者患有严重低血压。两组在复视，眼球震颤，幻觉，恶心和呕吐方面无显着差异。结论：结论：亚麻醉剂量的氯胺酮是一种有效的药物，可用于预防分娩CS的产妇的脊柱后低血压。

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